{"id":16551,"date":"2025-07-04T01:10:30","date_gmt":"2025-07-03T23:10:30","guid":{"rendered":"https:\/\/ethosherbals.com\/?p=16551"},"modified":"2025-07-04T01:13:57","modified_gmt":"2025-07-03T23:13:57","slug":"analgesic-alkaloids-tcm","status":"publish","type":"post","link":"https:\/\/ethosherbals.com\/fr\/wiki\/traditional-medicinal-herbs\/analgesic-alkaloids-tcm\/","title":{"rendered":"\u03a7\u03c1\u03cc\u03bd\u03b9\u03bf\u03c2 \u03a0\u03bf\u03bd\u03bf\u03c2 & \u0391\u03bd\u03b1\u03bb\u03b3\u03b7\u03c4\u03b9\u03ba\u03ac \u0391\u03bb\u03ba\u03b1\u03bb\u03bf\u03b5\u03b9\u03b4\u03ae \u03b1\u03c0\u03cc \u03ba\u03b9\u03bd\u03ad\u03b6\u03b9\u03ba\u03b1 \u0392\u03cc\u03c4\u03b1\u03bd\u03b1 TCM"},"content":{"rendered":"

\u03a0\u03c1\u03cc\u03bb\u03bf\u03b3\u03bf\u03c2<\/h2>\n\n\n\n

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L-Tetrahydropalmatine (L-THP)<\/h3>\n\n\n\n
\"\"<\/figure>\n\n\n\n

\u03a9\u03c2 \u03c4\u03bf \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 Corydalis yanhusuo<\/em> W.T.Wang [Papaveraceae; Corydalis rhizoma], \u03b7 \u03c4\u03b5\u03c4\u03c1\u03b1\u03cb\u03b4\u03c1\u03bf\u03c0\u03b1\u03bb\u03bc\u03b1\u03c4\u03af\u03bd\u03b7 (THP) \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03b5\u03b9 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ad\u03c2, \u03c5\u03c0\u03bd\u03c9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03b1\u03bd\u03b1\u03bb\u03b3\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b9\u03b4\u03b9\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03c3\u03b5 \u03c0\u03bf\u03b9\u03ba\u03af\u03bb\u03b1 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 \u03c0\u03cc\u03bd\u03bf\u03c5. \u0388\u03c7\u03b5\u03b9 \u03b4\u03bf\u03ba\u03b9\u03bc\u03b1\u03c3\u03c4\u03b5\u03af \u03bc\u03b5 \u03b5\u03bd\u03b8\u03b1\u03c1\u03c1\u03c5\u03bd\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c3\u03b5 \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 \u03c0\u03cc\u03bd\u03bf\u03c5 \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03bf\u03c3\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03cc \u03c0\u03cc\u03bd\u03bf , \u03c4\u03bf\u03bd \u03c0\u03cc\u03bd\u03bf \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c6\u03bf\u03c1\u03bc\u03b1\u03bb\u03af\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03bd\u03b5\u03c5\u03c1\u03bf\u03c0\u03b1\u03b8\u03b7\u03c4\u03b9\u03ba\u03cc \u03c0\u03cc\u03bd\u03bf. \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03ad\u03c1\u03b5\u03c5\u03bd\u03b5\u03c2 \u03c5\u03c0\u03bf\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03bf\u03c5\u03bd \u03c0\u03c9\u03c2 \u03b7 THP \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03bd\u03b1\u03c3\u03c4\u03c1\u03ad\u03c8\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd \u03b5\u03be\u03ac\u03c1\u03c4\u03b7\u03c3\u03b7 \u03b1\u03c0\u03cc \u03bf\u03c0\u03b9\u03bf\u03b5\u03b9\u03b4\u03ae \u03c3\u03b5 \u03b1\u03c1\u03bf\u03c5\u03c1\u03b1\u03af\u03bf\u03c5\u03c2 \u03b5\u03b8\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03c3\u03c4\u03b7 \u03bc\u03bf\u03c1\u03c6\u03af\u03bd\u03b7 (\u0394\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1: 1,25, 2,5, 5 mg\/kg\u00b7 \u0391\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03bc\u03ac\u03c1\u03c4\u03c5\u03c1\u03b1: \u03bc\u03bf\u03c1\u03c6\u03af\u03bd\u03b7) (Jiang WN. et al., 2020). \u0397 THP \u03ad\u03c7\u03b5\u03b9 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c3\u03c4\u03b7\u03bd \u039a\u03af\u03bd\u03b1 \u03c9\u03c2 \u03b1\u03bd\u03b1\u03bb\u03b3\u03b7\u03c4\u03b9\u03ba\u03cc, \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03cc \u03ae \u03c5\u03c0\u03bd\u03c9\u03c4\u03b9\u03ba\u03cc (Ren et al., 2003), \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b1\u03c1\u03c1\u03c5\u03b8\u03bc\u03b9\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7\u03c2 (Ren et al., 2003).<\/p>\n\n\n\n

Link \u03b1\u03b3\u03bf\u03c1\u03ac\u03c2 <\/strong>: https:\/\/ethosherbals.com\/shop\/herbs-for-the-spirit\/uplifted_mood\/tetrahydropalmatine-isolate\/<\/a><\/p>\n\n\n\n

Aloperine<\/h3>\n\n\n\n
\"\"<\/figure>\n\n\n\n

\u0397 \u0391\u03bb\u03bf\u03c0\u03b5\u03c1\u03af\u03bd\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03b1\u03bb\u03ba\u03b1\u03bb\u03bf\u03b5\u03b9\u03b4\u03ad\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1\u03c2 \u03c4\u03c9\u03bd \u03ba\u03b9\u03bd\u03bf\u03bb\u03b9\u03b6\u03b9\u03b4\u03b9\u03bd\u03ce\u03bd, \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c6\u03c5\u03c4\u03cc Sophora alopecuroides<\/strong> L. [\u039f\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1: Fabaceae|. \u03a3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b4\u03bf\u03c3\u03b9\u03b1\u03ba\u03ae \u03ba\u03b9\u03bd\u03b5\u03b6\u03b9\u03ba\u03ae \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae (TCM), \u03c4\u03bf \u03c6\u03c5\u03c4\u03cc Sophora alopecuroides<\/strong> L. \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b5\u03c4\u03b1\u03b9 \u03ae\u03b4\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf \u03b1\u03c1\u03c7\u03b1\u03af\u03bf \u03ad\u03c1\u03b3\u03bf \u201c\u03a4\u03b1 \u039a\u03bb\u03b1\u03c3\u03b9\u03ba\u03ac \u03c4\u03b7\u03c2 \u0392\u03bf\u03c4\u03b1\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 Shennong\u201d \u03c9\u03c2 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03bc\u03ad\u03c3\u03bf \u03c0\u03bf\u03c5 \u03b2\u03bf\u03b7\u03b8\u03ac \u03c3\u03c4\u03b7\u03bd \u03b5\u03be\u03b9\u03c3\u03bf\u03c1\u03c1\u03cc\u03c0\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c0\u03ad\u03bd\u03c4\u03b5 \u03b6\u03c9\u03c4\u03b9\u03ba\u03ce\u03bd \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03bd (\u03ae\u03c0\u03b1\u03c1, \u03ba\u03b1\u03c1\u03b4\u03b9\u03ac, \u03c3\u03c0\u03bb\u03ae\u03bd\u03b1, \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03bd\u03b5\u03c6\u03c1\u03ac), \u03b1\u03c0\u03bf\u03c4\u03bf\u03be\u03b9\u03bd\u03ce\u03bd\u03b5\u03b9 \u03c4\u03bf \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03b1\u03cd\u03b3\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03bd\u03bf\u03c5 (Wang et al., 2020).<\/p>\n\n\n\n

\u03a3\u03cd\u03b3\u03c7\u03c1\u03bf\u03bd\u03b5\u03c2 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03b1\u03bb\u03bf\u03c0\u03b5\u03c1\u03af\u03bd\u03b7 \u03b4\u03b9\u03b1\u03b8\u03ad\u03c4\u03b5\u03b9 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ae, \u03b1\u03bd\u03c4\u03b9\u03b2\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae, \u03b1\u03bd\u03c4\u03b9\u03b9\u03ba\u03ae, \u03b1\u03bd\u03c4\u03b9\u03bf\u03be\u03b5\u03b9\u03b4\u03c9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03bd\u03c4\u03b9\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03bb\u03b3\u03b7\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 (Xu et al., 2014; Zhou et al., 2020).<\/p>\n\n\n\n

\u039c\u03ad\u03c3\u03c9 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03ac\u03c4\u03c9\u03bd \u03c3\u03b5 \u03b6\u03c9\u03b9\u03ba\u03ac \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03b1, \u03b7 \u03bf\u03c5\u03c3\u03af\u03b1 \u03b1\u03c0\u03bf\u03b4\u03b5\u03af\u03c7\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03bf\u03c5\u03c2 \u03c0\u03cc\u03bd\u03bf\u03c5 \u03c3\u03b5 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b5\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf \u03c4\u03b5\u03c3\u03c4 \u03c0\u03b5\u03c1\u03b9\u03c4\u03bf\u03bd\u03b1\u03ca\u03ba\u03bf\u03cd \u03c0\u03cc\u03bd\u03bf\u03c5 \u03bc\u03b5 \u03bf\u03be\u03b9\u03ba\u03cc \u03bf\u03be\u03cd, \u03c4\u03bf \u03c4\u03b5\u03c3\u03c4 \u03c6\u03bf\u03c1\u03bc\u03b1\u03bb\u03af\u03bd\u03b7\u03c2, \u03b7 \u03b4\u03b9\u03cc\u03b3\u03ba\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03c5\u03c4\u03b9\u03bf\u03cd \u03c3\u03b5 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03bf\u03af\u03b4\u03b7\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03c0\u03ad\u03bb\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c1\u03b1\u03b3\u03b5\u03bd\u03ac\u03bd\u03b7 (\u03b4\u03cc\u03c3\u03b5\u03b9\u03c2: 20, 40, 80 mg\/kg\u00b7 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2: \u03b1\u03c3\u03c0\u03b9\u03c1\u03af\u03bd\u03b7 \u03ae \u03bc\u03bf\u03c1\u03c6\u03af\u03bd\u03b7) (Yang et al., 2015a), \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03bd\u03b5\u03c5\u03c1\u03bf\u03c0\u03b1\u03b8\u03b7\u03c4\u03b9\u03ba\u03cc \u03c0\u03cc\u03bd\u03bf \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c0\u03b5\u03c1\u03af\u03b4\u03b5\u03c3\u03b7 \u03bd\u03b5\u03cd\u03c1\u03bf\u03c5 (\u03af\u03b4\u03b9\u03b5\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2\u00b7 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c0\u03c1\u03b5\u03b3\u03ba\u03b1\u03bc\u03c0\u03b1\u03bb\u03af\u03bd\u03b7) (Xu et al., 2014). \u03a3\u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03ac\u03be\u03b7 \u03c3\u03c4\u03b7\u03bd \u039a\u03af\u03bd\u03b1, \u03b7 \u03b1\u03bb\u03bf\u03c0\u03b5\u03c1\u03af\u03bd\u03b7 \u03ad\u03c7\u03b5\u03b9 \u03b1\u03be\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03c9\u03bd \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03c9\u03bd, \u03cc\u03c0\u03c9\u03c2 \u03b7 \u03c1\u03b5\u03c5\u03bc\u03b1\u03c4\u03bf\u03b5\u03b9\u03b4\u03ae\u03c2 \u03b1\u03c1\u03b8\u03c1\u03af\u03c4\u03b9\u03b4\u03b1, \u03bf \u03b5\u03c1\u03c5\u03b8\u03b7\u03bc\u03b1\u03c4\u03ce\u03b4\u03b7\u03c2 \u03bb\u03cd\u03ba\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03ad\u03ba\u03b6\u03b5\u03bc\u03b1 (Jin et al., 2015; Wang et al., 2020).<\/p>\n\n\n\n

Link \u03b1\u03b3\u03bf\u03c1\u03ac\u03c2 :<\/strong> https:\/\/ethosherbals.com\/shop\/herbs-for-the-spirit\/mental-focus\/sophona-alopecuroides-aloperine\/<\/a><\/p>\n\n\n\n

Oxysophocarpine<\/h3>\n\n\n\n
\"\"<\/figure>\n\n\n\n

\u038c\u03c0\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03b7 \u03b1\u03bb\u03bf\u03c0\u03b5\u03c1\u03af\u03bd\u03b7, \u03ad\u03c4\u03c3\u03b9 \u03ba\u03b1\u03b9 \u03b7 \u03bf\u03be\u03c5\u03c3\u03bf\u03c6\u03bf\u03ba\u03b1\u03c1\u03c0\u03af\u03bd\u03b7 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c6\u03c5\u03c4\u03cc Sophora alopecuroides<\/strong> L. [\u039f\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1: Fabaceae] \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c6\u03c5\u03c4\u03cc Sophora Flavescens. \u0397 \u03bf\u03be\u03c5\u03c3\u03bf\u03c6\u03bf\u03ba\u03b1\u03c1\u03c0\u03af\u03bd\u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03b5\u03b9 \u03b1\u03be\u03b9\u03bf\u03c3\u03b7\u03bc\u03b5\u03af\u03c9\u03c4\u03b5\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03c4\u03b9\u03bf\u03be\u03b5\u03b9\u03b4\u03c9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b9\u03b4\u03b9\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2. \u0388\u03c7\u03b5\u03b9 \u03b2\u03c1\u03b5\u03b8\u03b5\u03af \u03cc\u03c4\u03b9 \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03b5\u03b9 \u03bd\u03b5\u03c5\u03c1\u03bf\u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7, \u03c0\u03c1\u03bf\u03c6\u03c5\u03bb\u03ac\u03c3\u03c3\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b1 \u03bd\u03b5\u03c5\u03c1\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b1\u03c0\u03cc \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7 \u03bb\u03cc\u03b3\u03c9 \u03ad\u03bb\u03bb\u03b5\u03b9\u03c8\u03b7\u03c2 \u03bf\u03be\u03c5\u03b3\u03cc\u03bd\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7\u03c2 (Zhu QL. et al., 2014\u00b7 Lu et al., 2017\u00b7 Zhao et al., 2018). \u0395\u03c0\u03af\u03c3\u03b7\u03c2, \u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03ae \u03c4\u03b7\u03c2 \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03ba\u03bb\u03b7\u03c3\u03b7 \u03c4\u03c1\u03b1\u03cd\u03bc\u03b1\u03c4\u03bf\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03c3\u03b5\u03b9 \u03c4\u03b7 \u03b2\u03bb\u03ac\u03b2\u03b7 \u03c3\u03c4\u03bf\u03bd \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03cc \u03b9\u03c3\u03c4\u03cc (Gao et al., 2017).<\/p>\n\n\n\n

\u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03b7 \u03bf\u03be\u03c5\u03c3\u03bf\u03c6\u03bf\u03ba\u03b1\u03c1\u03c0\u03af\u03bd\u03b7 \u03b4\u03c1\u03b1 \u03b1\u03bd\u03b1\u03bb\u03b3\u03b7\u03c4\u03b9\u03ba\u03ac, \u03b1\u03bd\u03b1\u03ba\u03bf\u03c5\u03c6\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03b1\u03c0\u03cc \u03bf\u03be\u03cd \u03c0\u03cc\u03bd\u03bf, \u03cc\u03c0\u03c9\u03c2 \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 \u03bc\u03b5 \u03c4\u03b5\u03c3\u03c4 \u00abtail-flick\u00bb \u03ba\u03b1\u03b9 \u03b8\u03b5\u03c1\u03bc\u03ae\u03c2 \u03c0\u03bb\u03ac\u03ba\u03b1\u03c2 (\u03b4\u03cc\u03c3\u03b5\u03b9\u03c2: 10, 40, 80 mg\/kg\u00b7 \u03bf\u03c5\u03c3\u03af\u03b1 \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2: \u03bc\u03bf\u03c1\u03c6\u03af\u03bd\u03b7) (Xu et al., 2013). \u0388\u03c7\u03b5\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03c7\u03b8\u03b5\u03af \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03b5 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7 \u03c0\u03cc\u03bd\u03bf, \u03cc\u03c0\u03c9\u03c2 \u03b7 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03ba\u03ae \u03b1\u03bb\u03bb\u03bf\u03b4\u03c5\u03bd\u03af\u03b1 \u03c3\u03b5 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03bf\u03af\u03b4\u03b7\u03bc\u03b1 \u03c0\u03ad\u03bb\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c1\u03b1\u03b3\u03b5\u03bd\u03ac\u03bd\u03b7 (\u03af\u03b4\u03b9\u03b5\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2\u00b7 \u03bf\u03c5\u03c3\u03af\u03b1 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2: \u03b1\u03c3\u03c0\u03b9\u03c1\u03af\u03bd\u03b7) (Yang et al., 2015b), \u03cc\u03c0\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03bf \u03c0\u03cc\u03bd\u03bf\u03c5 \u03b1\u03c0\u03cc \u03c6\u03bf\u03c1\u03bc\u03b1\u03bb\u03af\u03bd\u03b7 (\u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03bc\u03bf\u03c1\u03c6\u03af\u03bd\u03b7 \u03ae \u03b1\u03c3\u03c0\u03b9\u03c1\u03af\u03bd\u03b7) (Xu et al., 2013), \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf \u03c4\u03b5\u03c3\u03c4 \u03ba\u03bf\u03b9\u03bb\u03b9\u03b1\u03ba\u03ae\u03c2 \u03c3\u03cd\u03c3\u03c0\u03b1\u03c3\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03bf\u03be\u03b9\u03ba\u03cc \u03bf\u03be\u03cd (Xu et al., 2013). \u039c\u03ad\u03c7\u03c1\u03b9 \u03c3\u03c4\u03b9\u03b3\u03bc\u03ae\u03c2, \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b5\u03bd\u03c4\u03bf\u03c0\u03b9\u03c3\u03c4\u03b5\u03af \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac \u03b3\u03b9\u03b1 \u03ba\u03b1\u03bb\u03ac \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7\u03bd \u03bf\u03be\u03c5\u03c3\u03bf\u03c6\u03bf\u03ba\u03b1\u03c1\u03c0\u03af\u03bd\u03b7.<\/p>\n\n\n\n

Matrine<\/h3>\n\n\n\n
\"\"<\/figure>\n\n\n\n

\u0397 <\/strong>\u039c\u03b1\u03c4\u03c1\u03af\u03bd\u03b7<\/strong> \u03b1\u03bd\u03ae\u03ba\u03b5\u03b9 \u03c3\u03c4\u03b1 \u03b1\u03bb\u03ba\u03b1\u03bb\u03bf\u03b5\u03b9\u03b4\u03ae \u03c4\u03b7\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b1\u03c2 \u03c4\u03c9\u03bd \u03ba\u03b9\u03bd\u03bf\u03bb\u03b9\u03b6\u03b9\u03b4\u03b9\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03bc\u03bf\u03bd\u03ce\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c1\u03af\u03b6\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03c6\u03c5\u03c4\u03bf\u03cd Sophora flavescens<\/em> Ait. [\u039f\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1: Fabaceae\u00b7 \u03a1\u03af\u03b6\u03b1: Sophorae flavescentis radix]. \u0397 \u03b1\u03c0\u03bf\u03be\u03b7\u03c1\u03b1\u03bc\u03ad\u03bd\u03b7 \u03c1\u03af\u03b6\u03b1 \u03c4\u03bf\u03c5 \u03c6\u03c5\u03c4\u03bf\u03cd \u03b1\u03c5\u03c4\u03bf\u03cd \u03ba\u03b1\u03c4\u03b1\u03b3\u03c1\u03ac\u03c6\u03b5\u03c4\u03b1\u03b9 \u03ae\u03b4\u03b7 \u03c3\u03c4\u03bf \u03b1\u03c1\u03c7\u03b1\u03af\u03bf \u03b2\u03bf\u03c4\u03b1\u03bd\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c3\u03cd\u03b3\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1 \u201c\u03a4\u03b1 \u039a\u03bb\u03b1\u03c3\u03b9\u03ba\u03ac \u03c4\u03b7\u03c2 \u0392\u03bf\u03c4\u03b1\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 Shennong\u201d. \u0398\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c0\u03c9\u03c2 \u03b7 \u03c1\u03af\u03b6\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03c0\u03b9\u03ba\u03c1\u03ae \u03b3\u03b5\u03cd\u03c3\u03b7, \u03c8\u03c5\u03c7\u03c1\u03ae \u03c6\u03cd\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c9\u03c6\u03ad\u03bb\u03b9\u03bc\u03b5\u03c2 \u03b9\u03b4\u03b9\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c1\u03b5\u03c5\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03bf\u03cd, \u03c3\u03c4\u03b7 \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03cc\u03c1\u03b1\u03c3\u03b7\u03c2, \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03bd\u03af\u03c3\u03c7\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03ae\u03c0\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03c7\u03bf\u03bb\u03b7\u03b4\u03cc\u03c7\u03bf\u03c5 \u03ba\u03cd\u03c3\u03c4\u03b7\u03c2 (He et al., 2015). \u0397 \u03bc\u03b1\u03c4\u03c1\u03af\u03bd\u03b7 \u03ad\u03c7\u03b5\u03b9 \u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03c7\u03b8\u03b5\u03af \u03cc\u03c4\u03b9 \u03b5\u03c0\u03b9\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03b5\u03b9 \u03ad\u03bd\u03b1 \u03b5\u03c5\u03c1\u03cd \u03c6\u03ac\u03c3\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03b4\u03c1\u03ac\u03c3\u03b5\u03c9\u03bd, \u03cc\u03c0\u03c9\u03c2 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ae, \u03b1\u03bd\u03c4\u03b9\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7, \u03b1\u03bd\u03c4\u03b9-\u03b1\u03bb\u03bb\u03b5\u03c1\u03b3\u03b9\u03ba\u03ae, \u03b1\u03bd\u03c4\u03b9\u03b9\u03ba\u03ae, \u03b1\u03bd\u03c4\u03b9\u03ca\u03bd\u03c9\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03bb\u03b3\u03b7\u03c4\u03b9\u03ba\u03ae (Zhang et al., 2020a\u00b7 You et al., 2020). \u039f\u03b9 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03bf\u03c5\u03bd \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b1 \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd, \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf \u03bd\u03b5\u03c5\u03c1\u03b9\u03ba\u03cc, \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc.<\/p>\n\n\n\n

\u03a0\u03b9\u03bf \u03b1\u03bd\u03b1\u03bb\u03c5\u03c4\u03b9\u03ba\u03ac, \u03ad\u03c7\u03b5\u03b9 \u03c6\u03b1\u03bd\u03b5\u03af \u03cc\u03c4\u03b9 \u03b7 \u03bc\u03b1\u03c4\u03c1\u03af\u03bd\u03b7 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03c0\u03cc\u03bd\u03bf \u03c3\u03b5 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b1 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1, \u03cc\u03c0\u03c9\u03c2 \u03bf \u03bf\u03be\u03cd\u03c2 \u03c0\u03cc\u03bd\u03bf\u03c2 \u03c3\u03c4\u03bf \u03c4\u03b5\u03c3\u03c4 “tail-flick” (30 mg\/kg, \u03c3\u03c5\u03b3\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03cc: \u03c0\u03b5\u03c4\u03b1\u03b6\u03bf\u03ba\u03af\u03bd\u03b7) (Kamei et al., 1997), \u03ba\u03bf\u03b9\u03bb\u03b9\u03b1\u03ba\u03cc \u03ac\u03bb\u03b3\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03bf\u03be\u03b9\u03ba\u03cc \u03bf\u03be\u03cd (1, 3, 10 mg\/kg\u00b7 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c0\u03b5\u03c4\u03b1\u03b6\u03bf\u03ba\u03af\u03bd\u03b7) (Kamei et al., 1997\u00b7 Dai et al., 2021), \u03ba\u03b1\u03b9 \u03bf \u03bd\u03b5\u03c5\u03c1\u03bf\u03c0\u03b1\u03b8\u03b7\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c0\u03cc\u03bd\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b5\u03af\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03bf\u03c5\u03c3\u03af\u03b1 \u03b2\u03b9\u03bd\u03ba\u03c1\u03b9\u03c3\u03c4\u03af\u03bd\u03b7 (15, 30, 60 mg\/kg\u00b7 \u03c3\u03c5\u03b3\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03cc: \u03c0\u03c1\u03b5\u03b3\u03ba\u03b1\u03bc\u03c0\u03b1\u03bb\u03af\u03bd\u03b7) (Dun et al., 2014) \u03b5\u03af\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c7\u03c1\u03cc\u03bd\u03b9\u03bf \u03c4\u03c1\u03b1\u03c5\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03cc \u03c4\u03bf\u03c5 \u03bd\u03b5\u03cd\u03c1\u03bf\u03c5 (7.5, 15, 30 mg\/kg) (Wang et al., 2013a).<\/p>\n\n\n\n

\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac, \u03c3\u03c4\u03b7\u03bd \u039a\u03af\u03bd\u03b1, \u03b7 \u03bc\u03b1\u03c4\u03c1\u03af\u03bd\u03b7 \u03ad\u03c7\u03b5\u03b9 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 \u03b1\u03c4\u03c1\u03bf\u03c6\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03b2\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae\u03c2 \u03ba\u03bf\u03bb\u03c0\u03af\u03c4\u03b9\u03b4\u03b1\u03c2, \u03b2\u03bf\u03b7\u03b8\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c3\u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03bd, \u03ba\u03bd\u03b7\u03c3\u03bc\u03bf\u03cd \u03ba\u03b1\u03b9 \u03bf\u03b9\u03b4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae (Zhang and Shen, 2021). \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bb\u03cc\u03b3\u03c9 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ce\u03bd \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03c9\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03b5\u03b9\u03ce\u03bd, \u03cc\u03c0\u03c9\u03c2 \u03b7\u03c0\u03b1\u03c4\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1, \u03bd\u03b5\u03c5\u03c1\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03c4\u03bf \u03b1\u03bd\u03b1\u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 (You et al., 2020).<\/p>\n\n\n\n

Link \u03b1\u03b3\u03bf\u03c1\u03ac\u03c2 :<\/strong> https:\/\/ethosherbals.com\/shop\/herbs-for-the-body\/physical-energy\/sophona-matrine\/<\/a><\/p>\n\n\n\n

Sinomenine<\/h3>\n\n\n\n
\"\"<\/figure>\n\n\n\n

H <\/strong>\u03a3\u03b9\u03bdo\u03bc\u03b5\u03bd\u03af\u03bd\u03b7<\/strong> \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c1\u03af\u03b6\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c1\u03c1\u03b9\u03c7\u03ce\u03bc\u03b5\u03bd\u03bf\u03c5 \u03c6\u03c5\u03c4\u03bf\u03cd Sinomenium acutum<\/em> (Thunb.) Rehd. et Wils. [\u039f\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1: Menispermaceae\u00b7 Caulis: Sinomenii caulis]. \u039a\u03b1\u03c4\u03b1\u03b3\u03c1\u03ac\u03c6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03cc \u03ad\u03c1\u03b3\u03bf \u201cCompendium of Materia Medica\u201d \u03c9\u03c2 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03b3\u03b9\u03b1 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b1 \u03bd\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03b1, \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03c1\u03b5\u03c5\u03bc\u03b1\u03c4\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2 \u03b1\u03c1\u03b8\u03c1\u03af\u03c4\u03b9\u03b4\u03b1\u03c2 (Zhao et al., 2012). \u039f\u03b9 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03c4\u03b7\u03c2 \u03b9\u03b4\u03b9\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7, \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c4\u03b7\u03c2 \u03b1\u03c1\u03b8\u03c1\u03af\u03c4\u03b9\u03b4\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c3\u03af\u03b1 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03b7\u03c0\u03b1\u03c4\u03af\u03c4\u03b9\u03b4\u03b1\u03c2 (Zhao et al., 2012). \u0388\u03c1\u03b5\u03c5\u03bd\u03b5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03c3\u03b9\u03bd\u03bf\u03bc\u03b5\u03bd\u03af\u03bd\u03b7 \u03b1\u03bd\u03b1\u03ba\u03bf\u03c5\u03c6\u03af\u03b6\u03b5\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03c0\u03cc\u03bd\u03bf \u03c3\u03c4\u03b9\u03c2 \u03b1\u03c1\u03b8\u03c1\u03ce\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ad\u03c2 \u03bd\u03b5\u03c5\u03c1\u03b1\u03bb\u03b3\u03af\u03b1\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03b9\u03c3\u03c7\u03b9\u03b1\u03bb\u03b3\u03af\u03b1, \u03bf\u03c3\u03c6\u03c5\u03b1\u03bb\u03b3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c1\u03b5\u03c5\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2 \u03c4\u03c9\u03bd \u03bc\u03c5\u03ce\u03bd (Yamasaki, 1976).<\/p>\n\n\n\n

\u03a3\u03b5 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2, \u03c6\u03ac\u03bd\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03ad\u03c7\u03b5\u03b9 \u03b1\u03bd\u03b1\u03bb\u03b3\u03b7\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03bf\u03be\u03ad\u03bf\u03c2 \u03c0\u03cc\u03bd\u03bf\u03c5 (10, 20, 40 mg\/kg) (Gao et al., 2013\u00b7 Zhu Q. et al., 2014), \u03c0\u03cc\u03bd\u03bf\u03c5 \u03b1\u03c0\u03cc \u03c6\u03bf\u03c1\u03bc\u03b1\u03bb\u03af\u03bd\u03b7 (25, 50, 75 mg\/kg) (Lee et al., 2017), \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03bf\u03c5\u03c2 \u03c0\u03cc\u03bd\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bc\u03b5\u03bd\u03bf\u03c5 \u03b1\u03c0\u03cc CFA (30, 40 mg\/kg) (Li et al., 2017\u00b7 Yuan et al., 2018), \u03c0\u03cc\u03bd\u03bf\u03c5 \u03b1\u03c0\u03cc \u03c1\u03b5\u03c5\u03bc\u03b1\u03c4\u03bf\u03b5\u03b9\u03b4\u03ae \u03b1\u03c1\u03b8\u03c1\u03af\u03c4\u03b9\u03b4\u03b1 (10\u201380 mg\/kg) (Gao et al., 2015), \u03c7\u03b5\u03b9\u03c1\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03bf\u03cd \u03c0\u03cc\u03bd\u03bf\u03c5 (5\u201380 mg\/kg\u00b7 \u03c3\u03c5\u03b3\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ac: \u03bb\u03b9\u03b3\u03bf\u03c5\u03c3\u03c4\u03c1\u03b1\u03b6\u03af\u03bd\u03b7, \u03c0\u03b1\u03c1\u03b1\u03ba\u03b5\u03c4\u03b1\u03bc\u03cc\u03bb\u03b7) (Zhu et al., 2016\u00b7 Gao et al., 2021), \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 \u03c0\u03cc\u03bd\u03bf\u03c5 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03b1 \u03bf\u03c3\u03c4\u03ac \u03ba\u03b1\u03b9 \u03bd\u03b5\u03c5\u03c1\u03bf\u03c0\u03b1\u03b8\u03b7\u03c4\u03b9\u03ba\u03cc \u03c0\u03cc\u03bd\u03bf \u03c3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03b9\u03c6\u03ad\u03c1\u03b5\u03b9\u03b1 \u03ae \u03c4\u03bf \u03bd\u03c9\u03c4\u03b9\u03b1\u03af\u03bf \u03bc\u03c5\u03b5\u03bb\u03cc (Gao et al., 2013). \u0395\u03c0\u03b1\u03bd\u03b1\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03cc\u03bc\u03b5\u03bd\u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03ae \u03c4\u03b7\u03c2 \u03b4\u03b5\u03bd \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03b1\u03bd\u03bf\u03c7\u03ae \u03b1\u03bb\u03bb\u03ac \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf \u03ba\u03b1\u03c4\u03ce\u03c6\u03bb\u03b9 \u03c4\u03bf\u03c5 \u03c0\u03cc\u03bd\u03bf\u03c5 (Gao et al., 2014\u00b7 2019), \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03c0\u03bf\u03c5 \u03c4\u03b7\u03bd \u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac \u03c5\u03c0\u03bf\u03c8\u03ae\u03c6\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c7\u03c1\u03ae\u03c3\u03b7.<\/p>\n\n\n\n

\u0397 \u03ba\u03cd\u03c1\u03b9\u03b1 \u03b5\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03c4\u03b7\u03c2 \u03c3\u03b9\u03bd\u03bf\u03bc\u03b5\u03bd\u03af\u03bd\u03b7\u03c2 \u03c3\u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 \u03c1\u03b5\u03c5\u03bc\u03b1\u03c4\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2 \u03b1\u03c1\u03b8\u03c1\u03af\u03c4\u03b9\u03b4\u03b1\u03c2, \u03cc\u03c0\u03bf\u03c5 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c5\u03c0\u03b5\u03c1\u03ad\u03c7\u03b5\u03b9 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03c9\u03bd \u03bc\u03b7 \u03c3\u03c4\u03b5\u03c1\u03bf\u03b5\u03b9\u03b4\u03ce\u03bd \u03b1\u03bd\u03c4\u03b9\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03c9\u03b4\u03ce\u03bd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd \u03c3\u03b5 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03b9\u03bd\u03ae\u03c2 \u03b4\u03c5\u03c3\u03ba\u03b1\u03bc\u03c8\u03af\u03b1\u03c2, \u03c4\u03bf\u03c5 \u03b1\u03c1\u03b9\u03b8\u03bc\u03bf\u03cd \u03b5\u03c0\u03ce\u03b4\u03c5\u03bd\u03c9\u03bd \u03b1\u03c1\u03b8\u03c1\u03ce\u03c3\u03b5\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03a4\u039a\u0395 (Xu et al., 2008). \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03c0\u03b5\u03be\u03ac\u03c1\u03c4\u03b7\u03c3\u03b7 \u03b1\u03c0\u03cc \u03b7\u03c1\u03c9\u03af\u03bd\u03b7 (Liu Z. et al., 2007), \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd \u03b5\u03c1\u03c5\u03b8\u03b7\u03bc\u03b1\u03c4\u03ce\u03b4\u03bf\u03c5\u03c2 \u03bb\u03cd\u03ba\u03bf\u03c5 (Shi et al., 2008\u00b7 Zeng and Tong, 2020), \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03bf\u03c5\u03c1\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03c5\u03c1\u03af\u03b1\u03c2 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c3\u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b5\u03c2 (Yin et al., 2016).<\/p>\n\n\n\n

Ligustrazine<\/h3>\n\n\n\n
\"\"<\/figure>\n\n\n\n

H <\/strong>\u039b\u03b9\u03b3\u03bf\u03c5\u03c3\u03c4\u03c1\u03b1\u03b6\u03af\u03bd\u03b7<\/strong> \u03b5\u03be\u03ac\u03b3\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c6\u03c5\u03c4\u03cc Ligusticum chuanxiong<\/em> Hort. [\u039f\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1: Apiaceae\u00b7 \u03a1\u03af\u03b6\u03c9\u03bc\u03b1: Chuanxiong rhizoma] (Li et al., 2011) \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03c4\u03bf\u03c6\u03c5\u03ad\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b1\u03c1\u03c7\u03af\u03b1 \u03a3\u03b5\u03c4\u03c3\u03bf\u03c5\u03ac\u03bd \u03c4\u03b7\u03c2 \u039a\u03af\u03bd\u03b1\u03c2. \u03a0\u03b5\u03c1\u03b9\u03b3\u03c1\u03ac\u03c6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03c0\u03b5\u03c1\u03af\u03c6\u03b7\u03bc\u03bf \u03c3\u03cd\u03b3\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1 \u201c\u03a4\u03b1 \u039a\u03bb\u03b1\u03c3\u03b9\u03ba\u03ac \u03c4\u03b7\u03c2 \u0392\u03bf\u03c4\u03b1\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 Shennong\u201d \u03a4\u03bf \u03c1\u03af\u03b6\u03c9\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03c6\u03c5\u03c4\u03bf\u03cd \u03ad\u03c7\u03b5\u03b9 \u03b8\u03b5\u03c1\u03bc\u03ae \u03b9\u03b4\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03b9\u03ba\u03ac\u03bd\u03c4\u03b9\u03ba\u03b7 \u03b3\u03b5\u03cd\u03c3\u03b7. \u03a0\u03b1\u03c1\u03b1\u03b4\u03bf\u03c3\u03b9\u03b1\u03ba\u03ac, \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03bb\u03b1\u03ca\u03ba\u03ae \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03bd\u03af\u03c3\u03c7\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c1\u03b4\u03b9\u03bf-\u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2, \u03b5\u03bd\u03ce \u03ad\u03c7\u03b5\u03b9 \u03b2\u03c1\u03b5\u03b9 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae (Chen Z. et al., 2018).<\/p>\n\n\n\n

\u0397 \u03bb\u03b9\u03b3\u03bf\u03c5\u03c3\u03c4\u03c1\u03b1\u03b6\u03af\u03bd\u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03b5\u03b9 \u03b5\u03c5\u03c1\u03cd \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c6\u03ac\u03c3\u03bc\u03b1 \u03bc\u03b5 \u03b1\u03bd\u03c4\u03b9\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7, \u03b1\u03bd\u03c4\u03b9\u03bf\u03be\u03b5\u03b9\u03b4\u03c9\u03c4\u03b9\u03ba\u03ae, \u03bd\u03b5\u03c5\u03c1\u03bf\u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae, \u03b1\u03bd\u03c4\u03b9\u03ca\u03bd\u03c9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03bd\u03c4\u03b9\u03b2\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03bb\u03b3\u03b7\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 (Ozaki, 1992\u00b7 Jiang and Wang, 2016). \u03a0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac, \u03ad\u03c7\u03b5\u03b9 \u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03c7\u03b8\u03b5\u03af \u03cc\u03c4\u03b9 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03bd \u03c0\u03cc\u03bd\u03bf \u03b1\u03c0\u03cc \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c1\u03b1\u03b3\u03b5\u03bd\u03ac\u03bd\u03b7 (10, 20, 80 mg\/kg\u00b7 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c3\u03b9\u03bd\u03bf\u03bc\u03b5\u03bd\u03af\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03ba\u03b5\u03c4\u03b1\u03bc\u03cc\u03bb\u03b7) (Gao et al., 2021), \u03c7\u03b5\u03b9\u03c1\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03cc \u03c0\u03cc\u03bd\u03bf (\u03af\u03b4\u03b9\u03b5\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2) \u03ba\u03b1\u03b9 \u03bd\u03b5\u03c5\u03c1\u03bf\u03c0\u03b1\u03b8\u03b7\u03c4\u03b9\u03ba\u03cc \u03c0\u03cc\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03c1\u03b1\u03c5\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03cc \u03b9\u03c3\u03c7\u03b9\u03b1\u03ba\u03bf\u03cd \u03ae \u03bd\u03c9\u03c4\u03b9\u03b1\u03af\u03bf\u03c5 \u03bd\u03b5\u03cd\u03c1\u03bf\u03c5 \u03bc\u03b5 \u03c6\u03c9\u03c4\u03bf\u03c7\u03b7\u03bc\u03b9\u03ba\u03ae \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf (Gao et al., 2019). \u03a3\u03c4\u03b7\u03bd \u039a\u03af\u03bd\u03b1, \u03b7 \u03bb\u03b9\u03b3\u03bf\u03c5\u03c3\u03c4\u03c1\u03b1\u03b6\u03af\u03bd\u03b7 \u03ad\u03c7\u03b5\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03b1\u03be\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ce\u03bd \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03c9\u03bd \u03c4\u03bf\u03c5 \u03b5\u03b3\u03ba\u03b5\u03c6\u03ac\u03bb\u03bf\u03c5, \u03b5\u03bc\u03c6\u03c1\u03ac\u03b3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03bc\u03c5\u03bf\u03ba\u03b1\u03c1\u03b4\u03af\u03bf\u03c5, \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c1\u03b5\u03c5\u03bc\u03b1\u03c4\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2 \u03b1\u03c1\u03b8\u03c1\u03af\u03c4\u03b9\u03b4\u03b1\u03c2 (Li et al., 2009\u00b7 Zhang C. et al., 2019).<\/p>\n\n\n\n

Evodiamine<\/h3>\n\n\n\n
\"\"<\/figure>\n\n\n\n

\u0397 \u03b5\u03c5\u03bf\u03b4\u03b9\u03b1\u03bc\u03af\u03bd\u03b7<\/strong> (\u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 1) \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c4\u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03bf\u03c5\u03c3\u03af\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c6\u03c5\u03c4\u03bf\u03cd Tetradium ruticarpum<\/em> (A.Juss.) Hart. [\u039f\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1: Rutaceae\u00b7 \u039a\u03b1\u03c1\u03c0\u03cc\u03c2: Tetradii ruticarpi fructus]. \u03a4\u03bf \u03c6\u03c5\u03c4\u03cc \u03b1\u03c5\u03c4\u03cc \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b5\u03c4\u03b1\u03b9 \u03ae\u03b4\u03b7 \u03c3\u03c4\u03bf \u03b1\u03c1\u03c7\u03b1\u03af\u03bf \u03b2\u03bf\u03c4\u03b1\u03bd\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03ad\u03c1\u03b3\u03bf \u201c\u03a4\u03b1 \u039a\u03bb\u03b1\u03c3\u03b9\u03ba\u03ac \u03c4\u03b7\u03c2 \u0392\u03bf\u03c4\u03b1\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 Shennong\u201d \u03ba\u03b1\u03b9 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b5\u03b4\u03ce \u03ba\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b1\u03c0\u03cc 2000 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b4\u03bf\u03c3\u03b9\u03b1\u03ba\u03ae \u03ba\u03b9\u03bd\u03b5\u03b6\u03b9\u03ba\u03ae \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae. \u03a3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03b1\u03c1\u03c7\u03ad\u03c2 \u03c4\u03b7\u03c2 TCM, \u03c4\u03bf Tetradium ruticarpum<\/em> \u03b8\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c0\u03c9\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c0\u03bf\u03bb\u03b5\u03bc\u03ac \u03c4\u03bf \u00ab\u03b5\u03c3\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c8\u03cd\u03c7\u03bf\u03c2\u00bb, \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03b5\u03b9 \u03b1\u03bd\u03b1\u03ba\u03bf\u03cd\u03c6\u03b9\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03c0\u03cc\u03bd\u03bf, \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03bd\u03b1\u03c5\u03c4\u03af\u03b1, \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03cd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03c3\u03c0\u03bb\u03ae\u03bd\u03b1, \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1 Yang \u03ba\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03c1\u03bf\u03b9\u03b1 (Sun et al., 2020).<\/p>\n\n\n\n

\u03a9\u03c2 \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc \u03b5\u03bd\u03b5\u03c1\u03b3\u03cc \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03c6\u03c5\u03c4\u03bf\u03cd, \u03b7 \u03b5\u03c5\u03bf\u03b4\u03b9\u03b1\u03bc\u03af\u03bd\u03b7 \u03ad\u03c7\u03b5\u03b9 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03b9\u03c3\u03c4\u03b5\u03af \u03bc\u03b5 \u03b5\u03c5\u03bd\u03bf\u03ca\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c3\u03b5 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ad\u03c2 \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03b7 \u03b1\u03b8\u03b7\u03c1\u03bf\u03c3\u03ba\u03bb\u03ae\u03c1\u03c9\u03c3\u03b7, \u03b7 \u03bc\u03c5\u03bf\u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03b9\u03c3\u03c7\u03b1\u03b9\u03bc\u03b9\u03ba\u03ad\u03c2 \u03ae \u03b2\u03b1\u03bb\u03b2\u03b9\u03b4\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b5\u03c2 (Li \u03ba\u03b1\u03b9 Wang, 2020). \u0395\u03c0\u03af\u03c3\u03b7\u03c2, \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03b5\u03b9 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b9\u03b4\u03b9\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03bc\u03ad\u03c3\u03c9 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03ce\u03bd \u03cc\u03c0\u03c9\u03c2 \u03b7 \u03b5\u03c0\u03b1\u03b3\u03c9\u03b3\u03ae \u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03bf\u03cd \u03b8\u03b1\u03bd\u03ac\u03c4\u03bf\u03c5 (\u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7\u03c2), \u03b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03bf\u03c5 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03bf\u03cd \u03ba\u03cd\u03ba\u03bb\u03bf\u03c5, \u03b7 \u03c0\u03b1\u03c1\u03b5\u03bc\u03c0\u03cc\u03b4\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03bd\u03ad\u03c9\u03bd \u03b1\u03b9\u03bc\u03bf\u03c6\u03cc\u03c1\u03c9\u03bd \u03b1\u03b3\u03b3\u03b5\u03af\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03b5\u03be\u03ac\u03c0\u03bb\u03c9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (Li \u03ba\u03b1\u03b9 Wang, 2020).<\/p>\n\n\n\n

\u03a3\u03b5 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ac \u03c0\u03b5\u03b9\u03c1\u03ac\u03bc\u03b1\u03c4\u03b1 \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2 \u03bc\u03ad\u03c3\u03c9 \u03bc\u03b5\u03bc\u03b2\u03c1\u03b1\u03bd\u03ce\u03bd, \u03b7 \u03b5\u03c5\u03bf\u03b4\u03b9\u03b1\u03bc\u03af\u03bd\u03b7 \u03ad\u03c7\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c0\u03b5\u03c1\u03bd\u03ac \u03c4\u03bf\u03bd \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03b9\u03ba\u03cc \u03c6\u03c1\u03b1\u03b3\u03bc\u03cc (Sun et al., 2020), \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7 \u03bd\u03b5\u03c5\u03c1\u03bf\u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c4\u03b7\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7\u03c2 \u03bd\u03b5\u03c5\u03c1\u03bf\u03c4\u03c1\u03bf\u03c6\u03b9\u03ba\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03c9\u03b4\u03ce\u03bd \u03b4\u03b9\u03b5\u03c1\u03b3\u03b1\u03c3\u03b9\u03ce\u03bd (Li \u03ba\u03b1\u03b9 Wang, 2020). \u0391\u03c5\u03c4\u03cc \u03c5\u03c0\u03bf\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03b5\u03c5\u03bf\u03b4\u03b9\u03b1\u03bc\u03af\u03bd\u03b7 \u03b5\u03bd\u03b4\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03b7 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b4\u03b9\u03b1\u03c6\u03cc\u03c1\u03c9\u03bd \u03bc\u03bf\u03c1\u03c6\u03ce\u03bd \u03c0\u03cc\u03bd\u03bf\u03c5. \u03a0\u03c1\u03ac\u03b3\u03bc\u03b1\u03c4\u03b9, \u03ad\u03c7\u03b5\u03b9 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b7\u03b8\u03b5\u03af \u03cc\u03c4\u03b9 \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03b5\u03b9 \u03b1\u03bd\u03b1\u03bb\u03b3\u03b7\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c3\u03b5 \u03c4\u03b5\u03c3\u03c4 \u03b8\u03b5\u03c1\u03bc\u03ae\u03c2 \u03c0\u03bb\u03ac\u03ba\u03b1\u03c2 (\u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1: 5 mg\/kg) \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03bf \u03bd\u03b5\u03c5\u03c1\u03bf\u03c0\u03b1\u03b8\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c0\u03cc\u03bd\u03bf\u03c5 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c0\u03b1\u03ba\u03bb\u03b9\u03c4\u03b1\u03be\u03ad\u03bb\u03b7 (\u03af\u03b4\u03b9\u03b1 \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1) (Wu \u03ba\u03b1\u03b9 Chen, 2019).<\/p>\n\n\n\n

\u03a3\u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03ac\u03be\u03b7, \u03b7 \u03b5\u03c5\u03bf\u03b4\u03b9\u03b1\u03bc\u03af\u03bd\u03b7 \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03bd \u03c4\u03bf\u03c5 \u03b4\u03ad\u03c1\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03b2\u03bb\u03b5\u03bd\u03bd\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd. \u03a7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ac \u03cc\u03c0\u03c9\u03c2 \u03b7 \u03b5\u03c1\u03c5\u03b8\u03c1\u03bf\u03bc\u03b5\u03bb\u03b1\u03bb\u03b3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Raynaud (Yarosh et al., 2006), \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ac \u03b3\u03b9\u03b1 \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03c4\u03bf\u03bc\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd \u03b2\u03bb\u03b5\u03bd\u03bd\u03bf\u03b3\u03cc\u03bd\u03bf\u03c5, \u03cc\u03c0\u03c9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bf\u03b4\u03bf\u03bd\u03c4\u03af\u03c4\u03b9\u03b4\u03b1 \u03ba\u03b1\u03b9 \u03bf\u03c5\u03bb\u03af\u03c4\u03b9\u03b4\u03b1 (Zeligs, 2006).<\/p>\n\n\n\n

Link \u03b1\u03b3\u03bf\u03c1\u03ac\u03c2 : <\/strong>https:\/\/ethosherbals.com\/shop\/herbs-for-the-spirit\/uplifted_mood\/evodiamine-extract\/<\/a><\/p>\n\n\n\n

Tetrandrine<\/h3>\n\n\n\n
\"\"<\/figure>\n\n\n\n

\u0397 \u03c4\u03b5\u03c4\u03c1\u03b1\u03bd\u03b4\u03c1\u03af\u03bd\u03b7<\/strong> (\u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 1) \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03c6\u03c5\u03c3\u03b9\u03ba\u03cc \u03b1\u03bb\u03ba\u03b1\u03bb\u03bf\u03b5\u03b9\u03b4\u03ad\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1\u03c2 \u03c4\u03c9\u03bd \u03b4\u03b9\u03c2-\u03b2\u03b5\u03bd\u03b6\u03c5\u03bb\u03bf\u03b9\u03c3\u03bf\u03ba\u03b9\u03bd\u03bf\u03bb\u03b9\u03bd\u03ce\u03bd, \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b1\u03c0\u03bf\u03bc\u03bf\u03bd\u03ce\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c1\u03af\u03b6\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03c6\u03c5\u03c4\u03bf\u03cd Stephania tetrandra<\/em> S. Moore [\u039f\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1: Menispermaceae\u00b7 \u03a1\u03af\u03b6\u03b1: Stephaniae tetrandrae radix]. \u03a4\u03bf \u03c6\u03c5\u03c4\u03cc \u03b1\u03c5\u03c4\u03cc \u03ba\u03b1\u03c4\u03b1\u03b3\u03c1\u03ac\u03c6\u03b7\u03ba\u03b5 \u03b3\u03b9\u03b1 \u03c0\u03c1\u03ce\u03c4\u03b7 \u03c6\u03bf\u03c1\u03ac \u03c3\u03c4\u03bf \u03b1\u03c1\u03c7\u03b1\u03af\u03bf \u03ba\u03b5\u03af\u03bc\u03b5\u03bd\u03bf \u201c\u03a4\u03b1 \u039a\u03bb\u03b1\u03c3\u03b9\u03ba\u03ac \u03c4\u03b7\u03c2 \u0392\u03bf\u03c4\u03b1\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 Shennong\u201d \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03b4\u03bf\u03c3\u03b9\u03b1\u03ba\u03ac \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u039a\u03af\u03bd\u03b1 \u03c9\u03c2 \u03bb\u03b1\u03ca\u03ba\u03cc \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03bc\u03b5 \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03b7 \u03b5\u03bb\u03bf\u03bd\u03bf\u03c3\u03af\u03b1, \u03c4\u03b1 \u03bf\u03b9\u03b4\u03ae\u03bc\u03b1\u03c4\u03b1, \u03b7 \u03c5\u03b3\u03c1\u03ae \u03bc\u03bf\u03c1\u03c6\u03ae \u03bc\u03c0\u03ad\u03c1\u03b9-\u03bc\u03c0\u03ad\u03c1\u03b9, \u03b7 \u03b4\u03c5\u03c3\u03bf\u03c5\u03c1\u03af\u03b1, \u03c4\u03bf \u03ad\u03ba\u03b6\u03b5\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b4\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1 (Jiang Y. et al., 2020).<\/p>\n\n\n\n

\u03a9\u03c2 \u03ba\u03cd\u03c1\u03b9\u03bf \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03c6\u03c5\u03c4\u03bf\u03cd, \u03b7 \u03c4\u03b5\u03c4\u03c1\u03b1\u03bd\u03b4\u03c1\u03af\u03bd\u03b7 \u03ad\u03c7\u03b5\u03b9 \u03b5\u03c0\u03b9\u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03b5\u03cd\u03c1\u03bf\u03c2. \u0388\u03c7\u03bf\u03c5\u03bd \u03b1\u03bd\u03b1\u03c6\u03b5\u03c1\u03b8\u03b5\u03af \u03b5\u03ba\u03c4\u03b5\u03bd\u03ce\u03c2 \u03bf\u03b9 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03c4\u03b7\u03c2 \u03b9\u03b4\u03b9\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03c4\u03cc\u03c3\u03bf \u03c3\u03b5 \u03c0\u03b5\u03b9\u03c1\u03ac\u03bc\u03b1\u03c4\u03b1 in vitro<\/em> \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c3\u03b5 in vivo<\/em> \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1, \u03bc\u03b5 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03ba\u03b1\u03c4\u03ac \u03c0\u03bf\u03bb\u03bb\u03ce\u03bd \u03c4\u03cd\u03c0\u03c9\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 (Luan et al., 2020). \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03b2\u03c1\u03ad\u03b8\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03c4\u03b5\u03c4\u03c1\u03b1\u03bd\u03b4\u03c1\u03af\u03bd\u03b7 \u03ad\u03c7\u03b5\u03b9 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03b1\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7, \u03bc\u03ad\u03c3\u03c9 \u03c0\u03b1\u03c1\u03b5\u03bc\u03c0\u03cc\u03b4\u03b9\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03b2\u03bf\u03bb\u03ae\u03c2 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd \u03b1\u03c0\u03cc \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03b5\u03bb\u03ad\u03c7\u03b7 Mycobacterium tuberculosis<\/em> (Zhang Z. et al., 2015). \u03a0\u03ad\u03c1\u03b1 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03ac, \u03b7 \u03bf\u03c5\u03c3\u03af\u03b1 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03b5\u03b9 \u03b1\u03bd\u03c4\u03b9\u03bf\u03be\u03b5\u03b9\u03b4\u03c9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03bd\u03c4\u03b9\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7, \u03b1\u03bd\u03c4\u03b9\u03b1\u03bb\u03bb\u03b5\u03c1\u03b3\u03b9\u03ba\u03ae, \u03b1\u03bd\u03c4\u03b9\u03b4\u03b9\u03b1\u03b2\u03b7\u03c4\u03b9\u03ba\u03ae, \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03bb\u03b3\u03b7\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 (Xie et al., 2002\u00b7 Bhagya \u03ba\u03b1\u03b9 Chandrashekar, 2016).<\/p>\n\n\n\n

\u0397 \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03ac \u03c4\u03b7\u03c2 \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03c0\u03cc\u03bd\u03bf \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03b8\u03b7\u03ba\u03b5 \u03c3\u03b5 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 \u03bc\u03b5 \u03b6\u03ce\u03b1, \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf \u03c4\u03b5\u03c3\u03c4 \u03b8\u03b5\u03c1\u03bc\u03ae\u03c2 \u03c0\u03bb\u03ac\u03ba\u03b1\u03c2 (15, 30, 45 mg\/kg\u00b7 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03bc\u03bf\u03c1\u03c6\u03af\u03bd\u03b7) \u03ba\u03b1\u03b9 \u03c4\u03bf \u03c4\u03b5\u03c3\u03c4 \u03ba\u03bf\u03b9\u03bb\u03b9\u03b1\u03ba\u03ae\u03c2 \u03c3\u03cd\u03c3\u03c0\u03b1\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03bf\u03be\u03b9\u03ba\u03cc \u03bf\u03be\u03cd (\u03af\u03b4\u03b9\u03b5\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03af\u03b4\u03b9\u03bf \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2) (Zhao et al., 2014).<\/p>\n\n\n\n

\u03a3\u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03ac\u03be\u03b7, \u03b7 \u03c4\u03b5\u03c4\u03c1\u03b1\u03bd\u03b4\u03c1\u03af\u03bd\u03b7 \u03ad\u03c7\u03b5\u03b9 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03b9\u03b1\u03c7\u03b5\u03af\u03c1\u03b9\u03c3\u03b7 \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03c9\u03bd \u03cc\u03c0\u03c9\u03c2 \u03b7 \u03b1\u03c1\u03b8\u03c1\u03af\u03c4\u03b9\u03b4\u03b1, \u03bf\u03b9 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ad\u03c2 \u03b1\u03c1\u03c1\u03c5\u03b8\u03bc\u03af\u03b5\u03c2, \u03b7 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7, \u03b7 \u03c3\u03b9\u03bb\u03b9\u03ba\u03cc\u03b6\u03c9\u03c3\u03b7, \u03b7 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03ba\u03bf\u03bd\u03af\u03c9\u03c3\u03b7, \u03b7 \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae \u03af\u03bd\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b7 \u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03ae \u03b3\u03b1\u03c3\u03c4\u03c1\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c0\u03c5\u03bb\u03b1\u03af\u03b1 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 (Kong X. et al., 2020). \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b1\u03ba\u03cc\u03bc\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03ba\u03b5\u03bd\u03ac \u03c3\u03c4\u03b7 \u03b3\u03bd\u03ce\u03c3\u03b7 \u03bc\u03b1\u03c2 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1, \u03c4\u03b7 \u03b2\u03b9\u03bf\u03b4\u03b9\u03b1\u03b8\u03b5\u03c3\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03c2 \u03c4\u03b5\u03c4\u03c1\u03b1\u03bd\u03b4\u03c1\u03af\u03bd\u03b7\u03c2, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03cc\u03c3\u03bf\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c3\u03b5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2 (Luan et al., 2020).<\/p>\n\n\n\n

Link \u03b1\u03b3\u03bf\u03c1\u03ac\u03c2 : <\/strong>https:\/\/ethosherbals.com\/shop\/herbs-for-the-body\/weight-loss\/fang-ji\/<\/a><\/p>\n\n\n\n

Lappaconitine<\/h3>\n\n\n\n
\"\"<\/figure>\n\n\n\n

\u0397 \u03bb\u03b1\u03c0\u03b1\u03ba\u03bf\u03bd\u03b9\u03c4\u03af\u03bd\u03b7<\/strong> (\u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 1) \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03c6\u03c5\u03c3\u03b9\u03ba\u03cc \u03b1\u03bb\u03ba\u03b1\u03bb\u03bf\u03b5\u03b9\u03b4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03c0\u03bf\u03bc\u03bf\u03bd\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03c1\u03af\u03b6\u03b1 \u03c4\u03bf\u03c5 \u03c6\u03c5\u03c4\u03bf\u03cd Aconitum sinomontanum<\/em> Nakai [\u039f\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1: Ranunculaceae\u00b7 \u03a1\u03af\u03b6\u03b1: Aconiti sinomontani radix]. \u03a3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03b1\u03c1\u03c7\u03ad\u03c2 \u03c4\u03b7\u03c2 \u03a0\u03b1\u03c1\u03b1\u03b4\u03bf\u03c3\u03b9\u03b1\u03ba\u03ae\u03c2 \u039a\u03b9\u03bd\u03ad\u03b6\u03b9\u03ba\u03b7\u03c2 \u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae\u03c2 (TCM), \u03c4\u03bf \u03c6\u03c5\u03c4\u03cc \u03b1\u03c5\u03c4\u03cc \u03ad\u03c7\u03b5\u03b9 \u00ab\u03b8\u03b5\u03c1\u03bc\u03ae \u03ba\u03b1\u03b9 \u03be\u03b7\u03c1\u03ae\u00bb \u03b9\u03b4\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1, \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03c0\u03bf\u03c5 \u03c4\u03bf \u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03c8\u03cd\u03c7\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c9\u03c2 \u03b1\u03bd\u03b1\u03bb\u03b3\u03b7\u03c4\u03b9\u03ba\u03cc \u03ae \u03b1\u03bd\u03c4\u03b9\u03c1\u03c1\u03b5\u03c5\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc (Ono \u03ba\u03b1\u03b9 Satoh, 1988\u00b7 Nyirimigabo et al., 2015).<\/p>\n\n\n\n

\u0397 \u03bb\u03b1\u03c0\u03b1\u03ba\u03bf\u03bd\u03b9\u03c4\u03af\u03bd\u03b7 \u03ad\u03c7\u03b5\u03b9 \u03c3\u03c5\u03bd\u03b4\u03b5\u03b8\u03b5\u03af \u03bc\u03b5 \u03c0\u03bf\u03b9\u03ba\u03af\u03bb\u03b5\u03c2 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c1\u03c1\u03b5\u03c5\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae, \u03b1\u03bd\u03c4\u03b9\u03b1\u03c1\u03c1\u03c5\u03b8\u03bc\u03b9\u03ba\u03ae, \u03b1\u03bd\u03c4\u03b9\u03b5\u03c0\u03b9\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03bb\u03b3\u03b7\u03c4\u03b9\u03ba\u03ae (Nyirimigabo et al., 2015). \u038c\u03c4\u03b1\u03bd \u03c7\u03bf\u03c1\u03b7\u03b3\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c3\u03b5 \u03c4\u03c1\u03c9\u03ba\u03c4\u03b9\u03ba\u03ac \u03b5\u03af\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c3\u03c4\u03cc\u03bc\u03b1 \u03b5\u03af\u03c4\u03b5 \u03bc\u03b5 \u03c5\u03c0\u03bf\u03b4\u03cc\u03c1\u03b9\u03b1 \u03ad\u03bd\u03b5\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03c4\u03b7\u03ba\u03b5 \u03c3\u03b5 \u03c4\u03b5\u03c3\u03c4 \u03cc\u03c0\u03c9\u03c2 \u03b7 \u03b8\u03b5\u03c1\u03bc\u03ae \u03c0\u03bb\u03ac\u03ba\u03b1, \u03b7 \u03b5\u03bc\u03b2\u03ac\u03c0\u03c4\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bf\u03c5\u03c1\u03ac\u03c2 \u03c3\u03b5 \u03b6\u03b5\u03c3\u03c4\u03cc \u03bd\u03b5\u03c1\u03cc \u03ae \u03bf\u03b9 \u03c3\u03c5\u03c3\u03c0\u03ac\u03c3\u03b5\u03b9\u03c2 \u03b1\u03c0\u03cc \u03bf\u03be\u03b9\u03ba\u03cc \u03bf\u03be\u03cd, \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b5 \u03ad\u03bd\u03c4\u03bf\u03bd\u03b7 \u03b1\u03bd\u03b1\u03bb\u03b3\u03b7\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7, \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b1 \u03bc\u03b5 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7\u03c2 \u03bc\u03bf\u03c1\u03c6\u03af\u03bd\u03b7\u03c2 (Ono \u03ba\u03b1\u03b9 Satoh, 1988).<\/p>\n\n\n\n

\u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03b7 \u03bf\u03c5\u03c3\u03af\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03c7\u03b8\u03b5\u03af \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03b5 \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 \u03b6\u03ce\u03c9\u03bd \u03bc\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c4\u03bf\u03bd\u03b1\u03ca\u03ba\u03cc \u03c0\u03cc\u03bd\u03bf \u03b1\u03c0\u03cc \u03bf\u03be\u03b9\u03ba\u03cc \u03bf\u03be\u03cd (Ono \u03ba\u03b1\u03b9 Satoh, 1988) \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03bd\u03b5\u03c5\u03c1\u03bf\u03c0\u03b1\u03b8\u03b7\u03c4\u03b9\u03ba\u03cc \u03c0\u03cc\u03bd\u03bf \u03b1\u03c0\u03cc \u03c7\u03c1\u03cc\u03bd\u03b9\u03bf \u03c4\u03c1\u03b1\u03c5\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03cc \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03bf\u03cd \u03bd\u03b5\u03cd\u03c1\u03bf\u03c5 (CCI), \u03bc\u03b5 \u03b4\u03cc\u03c3\u03b7 4 mg\/kg (Ou et al., 2011).<\/p>\n\n\n\n

\u03a3\u03b5 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c0\u03b5\u03c1\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd, \u03b7 \u03bb\u03b1\u03c0\u03b1\u03ba\u03bf\u03bd\u03b9\u03c4\u03af\u03bd\u03b7 \u03ad\u03c7\u03b5\u03b9 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03bc\u03b5 \u03b5\u03c0\u03b9\u03c4\u03c5\u03c7\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03ba\u03bf\u03cd\u03c6\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bc\u03b5\u03c4\u03b5\u03b3\u03c7\u03b5\u03b9\u03c1\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c0\u03cc\u03bd\u03bf\u03c5 \u03bc\u03ad\u03c3\u03c9 \u03b5\u03c0\u03b9\u03c3\u03ba\u03bb\u03b7\u03c1\u03af\u03b4\u03b9\u03b1\u03c2 \u03ad\u03b3\u03c7\u03c5\u03c3\u03b7\u03c2, \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03bf\u03bd\u03c4\u03b1\u03c2 \u03b9\u03ba\u03b1\u03bd\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ac \u03b1\u03bd\u03b1\u03bb\u03b3\u03b7\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 (Chen et al., 1996).<\/p>\n\n\n\n

\u0395\u03c0\u03af\u03bb\u03bf\u03b3\u03bf\u03c2<\/h2>\n\n\n\n

\u038c\u03c0\u03c9\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af\u03c4\u03b5 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03ce\u03c3\u03b5\u03c4\u03b5, \u03b4\u03b9\u03b1\u03b8\u03ad\u03c4\u03bf\u03c5\u03bc\u03b5 \u03c4\u03b1 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03b1\u03bb\u03ba\u03b1\u03bb\u03bf\u03b5\u03b9\u03b4\u03ae \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b8\u03b7\u03ba\u03b1\u03bd \u03c0\u03b1\u03c1\u03b1\u03c0\u03ac\u03bd\u03c9 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b1\u03b4\u03b9\u03b1\u03ba\u03ac \u03b8\u03b1 \u03b2\u03ac\u03bb\u03bf\u03c5\u03bc\u03b5 \u03c4\u03b1 \u03b4\u03c5\u03bd\u03b1\u03c4\u03ac \u03bc\u03b1\u03c2 \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03c4\u03b1 \u03c6\u03ad\u03c1\u03bf\u03c5\u03bc\u03b5 \u03cc\u03bb\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b1 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 :). \u03a4\u03bf \u03b6\u03ae\u03c4\u03b7\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03c7\u03c1\u03cc\u03bd\u03b9\u03bf\u03c5 \u03c0\u03cc\u03bd\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03b8\u03ad\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03bc\u03b1\u03c2 \u03b1\u03c0\u03b1\u03c3\u03c7\u03bf\u0384\u03bb\u03b5\u03af \u03ad\u03bd\u03c4\u03bf\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af\u03c4\u03b5 \u03bd\u03b1 \u03b5\u03af\u03c3\u03c4\u03b5 \u03c3\u03af\u03b3\u03bf\u03c5\u03c1\u03bf\u03b9 \u03c0\u03c9\u03c2 \u03b8\u03b1 \u03b2\u03ac\u03b6\u03bf\u03c5\u03bc\u03b5 \u03c4\u03b1 \u03b4\u03c5\u03bd\u03b1\u03c4\u03ac \u03bc\u03b1\u03c2 \u03bd\u03b1 \u03c3\u03b1\u03c2 \u03ba\u03b1\u03b8\u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5 \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03b9\u03c2 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b5\u03c2 \u03c3\u03b1\u03c2!<\/p>\n\n\n\n

*\u03a0\u03b7\u03b3\u03ae \u03ba\u03cd\u03c1\u03b9\u03b1\u03c2 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1\u03c2 \u03ac\u03c1\u03b8\u03c1\u03bf\u03c5 <\/strong>: https:\/\/www.frontiersin.org\/journals\/pharmacology\/articles\/10.3389\/fphar.2022.851508\/full<\/a><\/p>\n\n\n\n

<\/p>","protected":false},"excerpt":{"rendered":"

\u03a0\u03c1\u03cc\u03bb\u03bf\u03b3\u03bf\u03c2 \u03a4\u03bf \u03c3\u03b1\u03c1\u03ac\u03ba\u03b9 \u03c4\u03bf\u03c5 \u03c7\u03c1\u03cc\u03bd\u03b9\u03bf\u03c5 \u03c0\u03cc\u03bd\u03bf\u03c5 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03be\u03b5\u03ba\u03b9\u03bd\u03ac \u03b1\u03c0\u03cc \u03c4\u03c1\u03b1\u03c5\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03cc, \u03c7\u03b5\u03b9\u03c1\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae \u03b5\u03c0\u03ad\u03bc\u03b2\u03b1\u03c3\u03b7, \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae \u03ae \u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b2\u03bb\u03ac\u03c0\u03c4\u03bf\u03c5\u03bd \u03c4\u03bf \u201c\u03b1\u03b9\u03c3\u03b8\u03b7\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03cc\u201d \u03ba\u03cd\u03ba\u03bb\u03c9\u03bc\u03b1<\/p>","protected":false},"author":1,"featured_media":16562,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[828],"tags":[2344,2341,2346,2343,2342],"class_list":["post-16551","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-traditional-medicinal-herbs","tag-analgesic-alkaloids","tag-chronic-pain","tag-tetrahydropalmatine","tag-2343","tag-2342"],"yoast_head":"\n\u03a7\u03c1\u03cc\u03bd\u03b9\u03bf\u03c2 \u03a0\u03bf\u03bd\u03bf\u03c2 & \u0391\u03bd\u03b1\u03bb\u03b3\u03b7\u03c4\u03b9\u03ba\u03ac \u0391\u03bb\u03ba\u03b1\u03bb\u03bf\u03b5\u03b9\u03b4\u03ae \u03b1\u03c0\u03cc \u03ba\u03b9\u03bd\u03ad\u03b6\u03b9\u03ba\u03b1 \u0392\u03cc\u03c4\u03b1\u03bd\u03b1 TCM - Ethos Herbals<\/title>\n<meta name=\"description\" content=\"\u03a3\u03b5 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03ac\u03c1\u03b8\u03c1\u03bf \u03b1\u03bd\u03b1\u03c6\u03b5\u03c1\u03cc\u03bc\u03b1\u03c3\u03c4\u03b5 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf \u03b5\u03cd\u03c1\u03bf\u03c2 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03c9\u03bd \u03b1\u03bd\u03b1\u03bb\u03b3\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd \u03b1\u03bb\u03ba\u03b1\u03bb\u03bf\u03b5\u03b9\u03b4\u03ce\u03bd \u03b1\u03c0\u03cc \u03ba\u03b9\u03bd\u03ad\u03b6\u03b9\u03ba\u03b1 \u03b2\u03cc\u03c4\u03b1\u03bd\u03b1 (TCM). \u039a\u03cd\u03c1\u03b9\u03bf \u03bc\u03ad\u03bb\u03b7\u03bc\u03b1 \u03bc\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5\u03c2 \u03bc\u03b5 \u03c4\u03bf \u03c7\u03c1\u03cc\u03bd\u03b9\u03bf \u03c0\u03cc\u03bd\u03bf.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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