Oroxylin A

Nootropic enthusiasts aiming to unlock sharper focus and mental clarity use Oroxylin A, a rare flavonoid extracted from Scutellaria baicalensis. Known for its nootropic and neuroprotective properties, Oroxylin A supports cognitive function, memory, and a calm, alert state of mind—without the jitters.

i) ✅ Primary Pharmacological Actions of Oroxylin A:

✅ Potential Benefits

• Mental Alertness
• Executive Memory
• Motivation

ii) Oroxylin A Primary Pharmacological Properties

1. Dopamine (DA)

• Action: Dopamine reuptake inhibitor (DRI)
• Effect: Increases extracellular dopamine levels, particularly in the prefrontal cortex
• Benefit: Enhances motivation, alertness, and working memory

2. GABA (γ-Aminobutyric Acid)

• Action: Negative allosteric modulator of GABA_A receptors
• Effect: Mildly reduces GABAergic inhibition
• Benefit: Promotes wakefulness and cognitive stimulation; may help counteract sedation

3. Glutamate / NMDA Receptors

• Action: Indirect modulation; may enhance long-term potentiation (LTP)
• Effect: Supports learning and memory processes
• Benefit: Potential nootropic effect via neuroplasticity support

iii) Oroxylin A Dosing Overview

Typical Dosage Range:

• Typical range: 10–50 mg per day
• Starting dose: Around 10 mg/day
• High-end dosage: Up to 100 mg/day (less common and not well studied)

Timing & Frequency:

Morning to Early Afternoon

• Why: Oroxylin A promotes alertness, focus, and wakefulness, so taking it earlier in the day avoids potential sleep disruption.
• Best Time:
  • First thing in the morning
  • Or 30 minutes before mentally demanding tasks

Avoid Late-Day 

• May interfere with sleep due to dopaminergic and stimulant-like effects

With or Without Food?

Best: On an Empty Stomach

• Why: Improves absorption speed and bioavailability
• How: Take 30–60 minutes before meals, especially in the morning

iv) ⚠️ Important Considerations & Warnings

• Do not combine with other stimulants (e.g., caffeine) without consulting a healthcare provider.
• May cause insomnia or restlessness if taken late in the day.
• Use caution if having a history of anxiety, hypertension, or neurological disorders.
• Avoid use if pregnant, nursing, or planning to become pregnant.
• If you are taking medications affecting dopamine, GABA, or serotonin, consult a qualified healthcare professional prior to use.
• Discontinue use if you experience dizziness, rapid heartbeat, irritability, or mood changes.