Synephrine 98%

Derived from bitter orange (Citrus aurantium), Synephrine is a natural alkaloid known for supporting energy, metabolism, and fat oxidation. Commonly used in thermogenic blends, it’s a popular choice for those seeking a mild stimulant effect without the harshness of caffeine. Ethos Herbals offers lab-tested Synephrine for consistent purity and potency.

i) Primary Pharmacological Actions of Synephrine:

Primary Action: Adrenergic Receptor Agonist

Synephrine acts primarily on adrenergic receptors, which are involved in the body’s “fight or flight” response. These receptors respond to catecholamines like epinephrine and norepinephrine.

✅ Agonist Activity:

⚠️ Unlike ephedrine or norepinephrine, synephrine has minimal activity at β1 and β2, making it less stimulating on the cardiovascular system.

🧪 Other Pharmacological Effects

1. Thermogenic Agent

   • Promotes fat oxidation and energy expenditure via β3 receptor activation.

2. Appetite Suppression

   • May reduce hunger through indirect CNS stimulation, though evidence is limited.

3. Mild CNS Stimulant

   • Increases alertness and energy without strong CNS overstimulation. Not significantly dopaminergic or serotonergic.

4. Metabolic Modulator

   • May enhance glucose uptake and basal metabolic rate.

❌ Not a Direct Agonist of Major Neurotransmitters:

• Dopamine: No significant direct binding or agonism

• Serotonin: No serotonergic activity

• GABA: No effect

• Acetylcholine: Unrelated pathway

Summary Table