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ISRIB
20,00 € – 33,00 €
Note: For research and educational purposes only. Not intended for human consumption.
ISRIB is a potent small molecule known for its ability to modulate the integrated stress response (ISR), a cellular defense pathway linked to cognitive function, memory, and resilience under stress. By restoring protein synthesis during cellular stress, ISRIB has shown promise in preclinical studies for supporting learning, memory consolidation, and neuroprotection
i) Primary Pharmacological Actions of ISRIB:
MIF-1 does not act as a direct agonist on classical neurotransmitter receptors, but it exerts significant neuromodulatory effects, especially involving dopaminergic, opioidergic, and melanocortin systems.
🧠 ISRIB: Neurotransmitter Activity & Pharmacological Actions
ISRIB (Integrated Stress Response Inhibitor) does not act as a direct agonist on any neurotransmitter receptors like dopamine, serotonin, GABA, or acetylcholine. Instead, its powerful effects stem from modulating intracellular signaling pathways—specifically the Integrated Stress Response (ISR)—which indirectly influences cognition, memory, and neural plasticity.
🧠 Pharmacological Profile of ISRIB
❌ No Direct Agonism of Neurotransmitters
ISRIB does not bind to or directly activate:
-
Dopamine receptors
-
Serotonin receptors
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GABA<sub>A</sub> or GABA<sub>B</sub> receptors
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Cholinergic or glutamate receptors
⚙️ Primary Mechanism of Action
🔹 Inhibition of eIF2α Phosphorylation Effects
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ISRIB restores normal protein synthesis by inhibiting the effects of phosphorylated eIF2α (eukaryotic initiation factor 2 alpha).
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Under stress, eIF2α becomes phosphorylated, slowing down protein synthesis to protect the cell. While protective short-term, chronic ISR activation impairs memory, learning, and regeneration.
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ISRIB acts downstream of eIF2α phosphorylation to re-activate the translation initiation complex, especially eIF2B.
🧬 Key Pharmacological Effects
| Action | Effect |
|---|---|
| Inhibits ISR (via eIF2B modulation) | Restores protein synthesis during stress |
| Enhances synaptic plasticity | Improves memory formation and consolidation |
| Supports cognitive recovery post-injury | Shown in TBI, aging, and neurodegeneration models |
| Reduces maladaptive stress response | May blunt chronic neuroinflammation and fatigue |
🧠 Neurological Benefits (Indirect)
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Cognitive enhancement (learning, memory consolidation)
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Neuroprotection in models of TBI, aging, Alzheimer’s
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Reverses ISR-induced impairments in protein translation
Summary Table
| System | Direct Action | Effect |
|---|---|---|
| Neurotransmitters | None | No direct binding or agonism |
| ISR / eIF2α-eIF2B axis | Inhibitory (indirect) | Restores translation, enhances memory |
| Cognitive function | Indirect enhancement | Improved LTP, recall, learning ability |
💊 ISRIB Dosing Overview
🔹 What is ISRIB?
ISRIB is a potent small molecule that modulates the Integrated Stress Response (ISR) by restoring normal protein synthesis via eIF2B activation. It’s been studied in models of cognitive decline, traumatic brain injury (TBI), and neurodegenerative disease.
📏 Typical Dosing in Research Settings
| Model / Use Case | Common Dose | Route |
|---|---|---|
| Cognitive enhancement (mice) | 2.5–5 mg/kg | Intraperitoneal (IP) |
| Neurodegeneration / TBI | 5 mg/kg | IP or subcutaneous |
| Hypothetical human scaling* | ~5–15 mg/day | Oral (extrapolated)** |
*Human oral dosing extrapolated via allometric scaling from murine data (no clinical trials confirm this).
**Bioavailability in humans is not well-established — assumed moderate to low if taken orally.
⏱️ Pharmacokinetics
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Onset: ~1–2 hours (in animal studies)
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Duration: ~20 hours effect window; some studies show sustained cognitive benefits days after a single dose
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Half-life: Estimated ~8–12 hours (in rodents)
🔁 Dosing Frequency
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Single dose studies show lasting cognitive effects for days.
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Short-course protocols (e.g., 3–5 days) are common in memory or TBI recovery models.
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Not intended for chronic daily use unless further studied.
⚠️ Important Considerations
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Research chemical only — not approved for medical use.
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Must be handled using appropriate laboratory standards.
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Stability: Store in a cool, dry, light-protected environment.
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Often dissolved in DMSO, PEG, or ethanol-based carriers for lab use.
| Συσκευασία |
500 mg. ,1000 mg. |
|---|
TECHNICAL SPECIFICATIONS :
| Aspect | Details |
|---|---|
| Product Name | ISRIB |
| CAS Number | 1597403-47-8 |
| Purity | >99% |
|
Test Method |
COA/Lcms/Nmr/HPLC/UV |
Ideal storage is done in refrigerator, in temperature 2-8 Celcius. Has to be labeled clearly at all times and be kept out of reach of children!
WHAT TO AVOID :
- Strong dopaminergic or serotonergic agents
DISCLAIMER :
As stated in the short description, this and other products of subsection of “Nootropics” in our e-shop are NOT intended for human consumption! Those products are available for collection purposes or for other lawful use for which the consumer has taken care to be explicitly informed on a personal level in every aspect that may be affecting them.
The information provided in the descriptions of products which can be found in “Nootropics” subsection – as available from ethosherbals.com, SMARTSHOP Main Category – is of an academic nature. This information is not intended to be used for human consumption of the products in question. It is not intended to diagnose, prevent or treat any medical condition. It is not intended to be a substitute for any medical treatment.
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