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MIF-1 Peptide
55,00 €
Note: For research and educational purposes only. Not intended for human consumption.
MIF-1 is a small neuropeptide studied for its potential to support mood regulation, cognitive clarity, and neuroprotective balance. Known for modulating dopamine activity and influencing the brain’s response to stress, MIF-1 has shown promise in experimental models of depression, Parkinson’s disease, and memory function.
i) Primary Pharmacological Actions of MIF-1:
MIF-1 does not act as a direct agonist on classical neurotransmitter receptors, but it exerts significant neuromodulatory effects, especially involving dopaminergic, opioidergic, and melanocortin systems.
🧠 MIF-1 : Neurotransmitter Activity & Pharmacological Actions
Neurotransmitter and Receptor Activity of MIF-1
🔹 1. Dopaminergic System – Indirect Modulator
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MIF-1 modulates dopamine receptor sensitivity, particularly D2 receptors.
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It has been shown to enhance dopamine transmission in the hypothalamus and limbic system, especially in states of dopaminergic imbalance (e.g., Parkinson’s models).
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Not a direct agonist, but enhances endogenous dopamine activity.
✅ Associated with improved mood, motivation, and motor function in animal and human studies.
🔹 2. Melanocortin System (Antagonist of α-MSH)
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Originally isolated as a melanocyte-inhibiting factor, MIF-1 blocks the effects of α-MSH (alpha-melanocyte stimulating hormone).
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May influence stress response, energy regulation, and inflammation via this pathway.
❌ No direct action on serotonin, norepinephrine, or GABA receptors.
🔹 3. Opioid System – Mixed Effects
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MIF-1 may have anti-opioid effects, meaning it can reduce or counteract the effects of opioids like morphine.
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This suggests a role in pain modulation, tolerance reversal, or opioid withdrawal research.
🧪 Other Pharmacological Actions
| Mechanism | Effect |
|---|---|
| Dopamine D2 modulation | ↑ Motivation, mood, motor control |
| Anti-opioid action | May reduce opioid-induced sedation or tolerance |
| Neuroprotective & antidepressant | Used in models of Parkinson’s and depression |
| Blood–brain barrier permeability | MIF-1 crosses the BBB effectively |
| Nootropic potential | May improve memory and cognitive performance |
🧬 Summary Table
| System / Target | Action |
|---|---|
| Dopamine D2 Receptors | Indirect modulator/enhancer |
| α-MSH / Melanocortin | Antagonist |
| Opioid Receptors | Indirect anti-opioid activity |
| Serotonin / GABA / NE | No direct action |
| Συσκευασία |
50 mg. |
|---|
TECHNICAL SPECIFICATIONS :
| Aspect | Details | |
|---|---|---|
| Product Name | MIF-1 | |
| CAS Number |
|
|
| Purity | >99% | |
|
Test Method |
COA/Lcms/Nmr/HPLC/UV |
Ideal storage is done in refrigerator, in temperature 2-8 Celcius. Has to be labeled clearly at all times and be kept out of reach of children!
WHAT TO AVOID :
- Strong dopaminergic or serotonergic agents
DISCLAIMER :
As stated in the short description, this and other products of subsection of “Nootropics” in our e-shop are NOT intended for human consumption! Those products are available for collection purposes or for other lawful use for which the consumer has taken care to be explicitly informed on a personal level in every aspect that may be affecting them.
The information provided in the descriptions of products which can be found in “Nootropics” subsection – as available from ethosherbals.com, SMARTSHOP Main Category – is of an academic nature. This information is not intended to be used for human consumption of the products in question. It is not intended to diagnose, prevent or treat any medical condition. It is not intended to be a substitute for any medical treatment.
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