Pinealon Peptide

💊 Pinealon Dosing Overview

🔹 What is Pinealon?

Pinealon is a synthetic tripeptide (Glu-Asp-Arg) studied for its ability to protect neurons, support memory, and modulate gene expression in the brain. It is of particular interest in research on cognitive aging, hypoxia, and neurodegeneration.

📏 Typical Research Dosing

⚠️ Most data comes from rodent and geriatric human clinical models in Eastern European/Russian literature.

⏱️ Pharmacokinetics

• Half-life: Short (likely minutes to hours)

• Onset: ~1–2 days into course for measurable effect (in models)

• Duration: Benefits often persist for 1–2 weeks post-cycle

🔁 Dosing Cycles

• Common protocol:
  10 days on → 20–30 days off → repeat as needed (e.g., 3–4x/year)

• Used cyclically to reduce biological aging markers and support long-term cognition.

⚠️ What to Avoid with Pinealon

❌ 1. Oral Ingestion

• Pinealon is a peptide and will be degraded by digestive enzymes if taken orally.

• Avoid capsules or powders not intended for subcutaneous or intranasal administration.

❌ 2. High-Dose Pro-Oxidant Substances

• Since Pinealon supports mitochondrial function and reduces oxidative stress, combining it with high doses of:

  • Iron supplements

  • Unbuffered vitamin C megadoses

  • Pro-oxidant herbs or drugs

  …may counteract its antioxidant effects.

⚠️ 3. CNS-Stimulating Drugs (with Caution)

• Combining Pinealon with high-dose stimulants (e.g., modafinil, amphetamines) may overstimulate the CNS, especially if used for cognitive enhancement.

• Monitor for side effects like insomnia, headache, or mental fatigue.

❌ 4. Unstable Solvents or Peptide Carriers

• Avoid dissolving Pinealon in non-sterile, acidic, or unbuffered solvents.

  • Use sterile saline or bacteriostatic water for SC use.

  • For nasal spray: use 0.9% NaCl, and avoid alcohol-based solutions unless diluted appropriately.

⚠️ 5. Other Gene-Regulating Peptides (Without Guidance)

• If stacking with other DNA/RNA-modulating peptides (e.g., Epitalon, Cortexin, Selank), be cautious:

  • Monitor for overlap or interaction

  • Use one at a time per cycle unless under structured protocol

⚠️ 6. Pregnancy, Breastfeeding, or Hormone-Sensitive Conditions

• Due to its role in cellular gene expression and anti-aging signaling, Pinealon should be avoided in:

  • Pregnant or breastfeeding individuals

  • Those with hormone-sensitive cancers or conditions (just precautionary — not proven unsafe, but unstudied)

✅ Safe With (Generally Well-Tolerated With):

• Mitochondrial support: CoQ10, PQQ, magnesium, ALCAR

• Mild nootropics: L-theanine, Lion’s Mane, Rhodiola

• Adaptogens or anti-aging compounds (e.g., Epitalon, NAD+ precursors), when cycled appropriately