SLU-PP-332

WHAT TO AVOID :

❌ 1. Overuse or Chronic High Doses

• 5-Amino-1MQ increases NAD⁺ levels and modulates metabolism — great for fat loss and cellular energy.

• But chronic high-dose use may:

  • Overstimulate metabolic pathways

  • Alter methylation balance (since NNMT is tied to methyl donor cycling)

  • Lead to unintended side effects like fatigue, irritability, or hormonal imbalance

✅ Stick to researched dosing windows (typically 10–20 mg/day for short cycles in animal models)

❌ 2. Concurrent Use with Other NNMT Inhibitors or Methylation Modulators

• Combining with supplements or drugs that also inhibit NNMT or alter methylation (e.g., SAMe, niacin, methylfolate, resveratrol) could lead to:

  • Excess NAD⁺ accumulation

  • Methyl donor depletion

  • Unpredictable metabolic effects

⚠️ Use caution and monitor methylation-related pathways if stacking

❌ 3. Use in Hormone-Sensitive or Cancer Conditions

• NNMT is implicated in tumor metabolism and cancer cell survival in some contexts.

• While 5-Amino-1MQ may reduce fat cell expansion, it could theoretically affect tumor metabolism, especially in hormone-sensitive tissues.

❌ Avoid use in active cancer, estrogen-sensitive conditions, or without supervision in at-risk populations

❌ 4. Poor Storage & Handling

• 5-Amino-1MQ is light- and moisture-sensitive:

  • Avoid storing in hot, humid, or bright environments

  • Once reconstituted, must be refrigerated and used within 1–2 weeks

⚠️ 5. Use During Pregnancy or Breastfeeding

• No safety data exists.

• The metabolic impact and gene expression changes may pose unknown risks during fetal development.

❌ Do not use during pregnancy, breastfeeding, or in children

❌ 6. Combining with Fat-Burning Stimulants (without monitoring)

• Combining with:

  • Yohimbine

  • Clenbuterol

  • High-dose caffeine or ephedrine

…may overactivate fat oxidation and stress pathways, leading to:

• Jitteriness

• Adrenal fatigue

• Sleep disruption

🟡 Use caution when stacking with other metabolic stimulants