N-Acetyl Semax

WHAT TO AVOID :

❌ 1. Strong Dopaminergic Stimulants

• NA-Semax already enhances dopamine tone (indirectly).

• Combining it with powerful dopaminergic agents like:

  • Amphetamines (e.g., Adderall)

  • Methylphenidate (Ritalin)

  • High-dose L-DOPA or Selegiline

…may overstimulate the CNS, leading to:

• Anxiety

• Irritability

• Sleep disruption

🟡 Mild stimulants like caffeine or low-dose modafinil may be okay with caution.

❌ 2. Chronic Daily Use Without Cycling

• While Semax is not habit-forming, continuous long-term use can diminish effects over time (receptor desensitization or blunting of BDNF upregulation).

• Suggested cycle: 5–10 days on, 5+ days off or 4–6 weeks on, 2–4 weeks off

❌ 3. Use Near Bedtime

• NA-Semax can increase wakefulness, alertness, and dopamine signaling, which may interfere with sleep if taken in the evening.

🕒 Best used in the morning or early afternoon.

⚠️ 4. Mixing with Strong Serotonergic Agents

• While it does not directly increase serotonin, its anti-fatigue and mood-lifting effects may interact with SSRIs, SNRIs, or 5-HTP in unpredictable ways.

• Be cautious combining with:

  • SSRIs (e.g., fluoxetine)

  • MAOIs

  • Serotonin-enhancing stacks

❌ 5. Unstable Storage or Improper Reconstitution

• Peptides are delicate:

  • Keep refrigerated (2–8°C once reconstituted)

  • Use sterile bacteriostatic water for reconstitution

  • Avoid repeated freeze-thaw cycles

🧊 Improper storage reduces potency or causes degradation.

⚠️ 6. Use in Pregnancy or Hormone-Sensitive Conditions

• No safety data exists for pregnancy, breastfeeding, or endocrine-sensitive illnesses.

• Avoid use in these populations.