Resveratrol

Derived from the skin of red grapes and other botanicals, Resveratrol is a powerful antioxidant known for its anti-aging and heart health benefits. It supports cellular health, healthy inflammation response, and overall vitality.

i) ✅ Primary Pharmacological Actions of Resveratrol:

✅ Potential Benefits

• Powerful Antioxidant – Protects cells from oxidative stress and free radical damage.

• Heart Health – Supports healthy blood pressure, circulation, and cholesterol levels.

• Anti-Aging Properties – May activate longevity genes and support youthful cellular function.

• Brain Support – Promotes cognitive function and protects against age-related decline.

• Anti-Inflammatory – Helps reduce inflammation and support immune balance.

• Blood Sugar Regulation – May aid in maintaining healthy blood glucose levels.

ii) Resveratrol Primary Pharmacological Properties

While not a direct agonist, resveratrol influences:

1. Dopamine

• Enhances dopaminergic activity by protecting dopaminergic neurons.

• May increase dopamine availability in the brain, possibly by inhibiting monoamine oxidase (MAO).

2. Serotonin

• Upregulates serotonin receptors (5-HT1A and 5-HT2A) in some animal models.

• May increase serotonin levels indirectly via MAO inhibition or anti-inflammatory action.

3. Norepinephrine

• Modulates the noradrenergic system and may help normalize stress responses.

• May contribute to antidepressant-like effects in rodent studies.

4. Glutamate and GABA

• Has neuroprotective effects against glutamate excitotoxicity.

• May enhance GABAergic tone, though not through direct GABA receptor agonism.

iii) Resveratrol Dosing Overview

iv) Important Considerations & Warnings

• People with hormone-sensitive conditions – Resveratrol has mild estrogenic activity, so consult a physician if you have breast, ovarian, or prostate cancer.

• People on anticoagulants or antiplatelet drugs – May enhance blood thinning effects (e.g., with warfarin, aspirin, clopidogrel).

• Diabetics on medication – May lower blood sugar; monitor glucose levels if combining with antidiabetic drugs.

• Autoimmune conditions – Due to immune-modulating properties, consult a provider before use.