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4F-Phenibut

9,50 30,00 

Note: For research and educational purposes only. Not intended for human consumption.

Description

4F-Phenibut is a refined derivative of Phenibut known for its balanced nootropic effects. Sought after for its ability to promote relaxation, improve mood, and support restful sleep, 4F-Phenibut is a popular choice for those looking to reduce stress without drowsiness.

i) ✅ Primary Pharmacological Actions of 4F-Phenibut:

Potential Benefits

  • Neuroprotective Properties: Through GABA<sub>B</sub> activation and calcium channel modulation, Phenibut may help reduce neuronal excitotoxicity.

  • Stress Response Regulation: Some research suggests Phenibut can reduce the physiological response to stress (possibly through hypothalamic-pituitary-adrenal axis modulation).

  • Nootropic Effects: Users often report enhanced cognitive function under stress, likely due to the reduction in anxiety and improvement in focus from dopamine activity.

ii) 4F-Phenibut Primary Pharmacological Properties

 1. GABA (γ-Aminobutyric Acid) System

  • Primary action: GABAB_B receptor agonist

  • Like Phenibut, 4F-Phenibut binds primarily to the GABAB_B receptors (not GABAA_A), producing anxiolytic, sedative, and muscle relaxant effects.

  • The fluorine at the 4-position seems to increase lipophilicity, possibly improving blood-brain barrier penetration or altering receptor affinity slightly.

 2. Dopamine System

  • There is indirect evidence (and anecdotal support) that Phenibut can increase dopamine levels via action in the striatum or by modulating presynaptic GABAergic tone.

  • It’s likely that 4F-Phenibut has similar dopaminergic modulation, which may contribute to its euphoriant and motivational effects at higher doses.

iii) 4F-Phenibut Dosing Overview

Dose Level Amount (oral) Effects
Threshold 50–100 mg Light relaxation, mild anxiolysis
Light 100–250 mg Mild anxiolysis, social ease, minor sedation
Common 250–500 mg Anxiolytic, calming, pro-social, slightly euphoric

Timing & Frequency:

  • NO MORE THAN 2 TIMES PER WEEK. IDEALLY ONCE EVERY 7-10+ DAYS

iv) ⚠️ Important Considerations & Warnings

Not for Daily Research

  • Phenibut can build tolerance quickly and may lead to dependence if taken too frequently.

  • Recommended usage: No more than 1–2 times per week, with at least 3 days between doses.

Do Not Redose

  • Phenibut has a delayed onset (2–4 hours orally). Re-dosing too soon can lead to overdose symptoms including extreme sedation, motor impairment, or nausea.

  • Chronic or daily use may result in physical dependence, and sudden discontinuation can lead to serious withdrawal symptoms (anxiety, insomnia, tremors, seizures in extreme cases).

  • Avoid prolonged or escalating use.

CNS Depressant Warning

  • Phenibut is a central nervous system depressant. Combining it with other depressants (e.g., alcohol, benzodiazepines, opioids) can be dangerous or fatal.

Not for Use with MAOIs or GABAergic Medications

  • Avoid combining with medications or supplements that affect GABA, serotonin, or dopamine systems without consulting a medical professional.

Additional information
Packaging

1 g.

,

2 g.

,

4g.

TECHNICAL SPECIFICATIONS :

TECHNICAL SPECIFICATIONS :

Aspect Details
Product Name
4F-Phenibut
CAS

1858241-03-8

Purity 99%
Test Method HPLC

 

Ideal storage is done in a cool and dry place, away from direct sunlight and heat. Has to be labeled clearly at all times and be kept out of reach of children!

WHAT TO AVOID :

WHAT TO AVOID :

  • Alcohol
  • Benzodiazepines
  • MAOI medications
  • Other GABA ergic medications
DISCLAIMER :

DISCLAIMER :

As stated in the short description, this and other products of subsection of
“Nootropics” in our e-shop are NOT intended for human consumption! Those products are available for collection purposes or for other lawful use for which the consumer has taken care to be explicitly informed on a personal level in every aspect that may be affecting them.

The information provided in the descriptions of products which can be found into “Nootropics” subsection – as available from ethosherbals.com, SMARTSHOP Main Category– is of an academic nature. This information is not intended to be used for human consumption of the products in question. It is not intended to diagnose, prevent or treat any medical condition. It is not intended to be a substitute for any medical treatment.


											
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