Sophona Alopecuroides – Cytisine 98%

RECOMMENDED USAGE

*Cytisine can be dissolved in physiological serum (saline solution) for volumetric dosing. In this case, it is recommended that 1,5 mg of Cytisine is dissolved in 1 ml of physiological serum. Someone could start by dissolving 75 mg of Cytisine in 50 ml of physiological serum.

The “official” protocol of smoking cessation with Cytisine is as follows: 

Standard 25-Day Titration Protocol

• Dosage: 1.5 mg (1 ml if dissolved in physiological serum as stated above).

• Duration: 25 days, with gradually decreasing frequency:

  • Days 1–3: 1 dosage every 2 hours while awake – up to 6 dosages per day.

  • Days 4–12: 1 dosage every 2.5 hours – up to 5 dosages per day.

  • Days 13–16: 1 dosage every 3 hours – up to 4 dosages per day.
    

  • Days 17–20: 1 dosage every 5 hours – up to 3 dosages per day.

  • Days 21–25: Just 1 to 2 dosages per day.
    

• Implementation Advice: The treatment usually begins with a “quit date” set by Day 5. Continued smoking during the regimen is discouraged, as it can worsen side effects.
  

WHO Classification & Endorsement

• WHO Inclusion: In 2024, the WHO’s Clinical Treatment Guideline for Tobacco Cessation (and the WHO Essential Medicines List) recognized cytisine as a strongly recommended pharmacological option alongside NRT, varenicline, and bupropion.
  ILCN.org (ILCN/WCLC)+6WHO+6ClinicalTrials.gov+6

Simplified or Alternative Regimens (Emerging Evidence)

• Three-Times-Daily (TID) Schedule: Clinical trials have tested a simpler regimen—taking cytisine at higher doses three times daily:

  • 3 mg three times per day (TID) for 25 days showed superior continuous abstinence rates, with 30% quitting sustained through weeks 4–8 vs. 8% with placebo.
    ClinicalTrials.govPMC+1

• Extended Duration Regimens: Longer protocols of 6 to 12 weeks (like in ACH‑CYT‑03 Phase 3 trials) are being investigated to potentially improve long-term abstinence success.
  ClinicalTrials.gov+10ClinicalTrials.gov+10AAFP+10

• Experimental 40-Day Schedule: Some studies have explored extended or modified dose-scaling regimens over 40 days, though these are still experimental.
  ClinicalTrials.gov+4tobaccopreventioncessation.com+4SAGE Journals+4

Summary Table

Key Clinical Insights

• The 25-day downward titration is the most commonly used and studied protocol across many European countries.
  ILCN.org (ILCN/WCLC)+2PMC+2AAFP+4ClinicalTrials.gov+4PMC+4

• The TID 3 mg regimen may offer improved quitting rates and simpler administration.
  ClinicalTrials.govPMC

• WHO’s endorsement of cytisine—given its proven effectiveness, safety profile, and cost-efficiency—supports its inclusion as a key smoking cessation option globally.
  PMC+4WHO+4ClinicalTrials.gov+4