Nicotinamide Mononucleotide (NMN)

12,50 22,00 

Note: For research and educational purposes only. Not intended for human consumption.

Περιγραφή

Nicotinamide Mononucleotide (NMN) is a bioactive nucleotide derived from ribose and nicotinamide. As a direct precursor to Nicotinamide Adenine Dinucleotide (NAD+), NMN plays a central role in cellular metabolism and energy production. NAD+ levels have been studied in relation to aging, DNA repair, and mitochondrial function. This compound is commonly used in research exploring metabolic health, cellular resilience, and age-associated biological processes.

i) ✅ Primary Pharmacological Actions of Nicotinamide Mononucleotide:

Potential Benefits

1. Supports Cellular Energy Production

  • NMN boosts NAD⁺ levels, which are essential for mitochondrial function and ATP synthesis.

  • Enhanced energy metabolism may improve overall cellular performance.

2. Promotes Healthy Aging

  • NAD⁺ levels decline with age; NMN supplementation may help maintain youthful cellular function.

  • Associated with support for DNA repair, telomere maintenance, and sirtuin activation (SIRT1).

3. Enhances Metabolic Function

  • May improve insulin sensitivity, glucose tolerance, and lipid metabolism.

  • Studied for potential roles in metabolic disorders and age-related insulin resistance.

4. Neuroprotective Potential

  • Through NAD⁺-dependent pathways, NMN may help protect neurons from oxidative stress and support cognitive function.

  • Research shows possible benefits in brain aging and neuroinflammation models.

5. Supports Cardiovascular Health

  • NAD⁺ is involved in vascular function, endothelial cell health, and nitric oxide production.

  • NMN has shown potential in improving blood flow and vascular elasticity in animal studies.

6. Improves Physical Performance (in preclinical studies)

  • May enhance muscle endurance, mitochondrial density, and fatigue resistance.

  • Relevant in research on exercise physiology and sarcopenia.

7. Helps Combat Oxidative Stress

  • NAD⁺ is vital for maintaining redox balance and activating antioxidant defenses.

  • NMN may reduce cellular damage under oxidative or inflammatory conditions.

ii) NMN Primary Pharmacological Properties

  • NMN is a biosynthetic intermediate in the salvage pathway that converts nicotinamide into NAD⁺, a critical coenzyme in redox reactions and energy metabolism.

  • By raising intracellular NAD⁺, NMN influences various cellular processes, including:

    • Mitochondrial function

    • Oxidative stress response

    • DNA repair

    • Cell survival

      While NMN does not bind to or activate neurotransmitter receptors directly, elevated NAD⁺ levels can affect the nervous system through several downstream mechanisms:

      1. Sirtuin Activation (Especially SIRT1)

        • SIRT1 modulates neuroinflammation, synaptic plasticity, and circadian rhythm.

        • May indirectly influence neurotransmission and neuroprotection.

      2. PARP Inhibition

        • Poly(ADP-ribose) polymerases consume NAD⁺ during DNA repair.

        • NMN may reduce excessive PARP activity, preventing NAD⁺ depletion in neurons under stress.

      3. Mitochondrial Biogenesis

        • Enhanced mitochondrial function supports ATP production in neurons, indirectly supporting neurotransmitter synthesis and release.

iii) 💊 NMN Dosing Overview

Dose Range Typical Use
125 mg/day Low-dose studies (general NAD⁺ support)
250–500 mg/day Common range in clinical trials
750–1000 mg/day Higher-end used in some trials without serious adverse effects

 


iv) ⚠️ Important Considerations & Warnings

1. Individual Variability

  • Response may depend on age, metabolic health, baseline NAD⁺ levels, and genetic factors.

  • Those with methylation issues or pre-existing conditions should consult a healthcare provider before use.

2. Side Effects (Rare)

  • Reported side effects are generally mild in clinical studies:

    • Nausea

    • Headache

    • GI discomfort

    • Flushing (less common than niacin)

  • Long-term effects are still being evaluated.

3. Pharmaceutical Interactions

    • No well-established drug interactions, but theoretical interactions may exist due to its role in NAD⁺ metabolism.

    • Caution advised in conjunction with chemotherapeutics, PARP inhibitors, or immune-modulating agents.

🧠 Common Reported Effects

Positive Potential Side Effects
Enhanced memory and recall Headache (often choline-related)
Increased focus and clarity Irritability or brain fog (rare)
Reduced anxiety in some users Insomnia (if taken too late)
Επιπρόσθετες Πληροφορίες
Συσκευασία

4,5 g.

,

9 g.

TECHNICAL SPECIFICATIONS :

TECHNICAL SPECIFICATIONS :

Aspect Details
Product Name
Nicotinamide Mononucleotide
CAS

1094-61-7

Purity 99%
Test Method HPLC
WHAT TO AVOID :

WHAT TO AVOID :

  • Avoid stacking NMN with other NAD⁺ precursors like NR (Nicotinamide Riboside), niacin, or nicotinamide unless dosing is carefully managed. Overactivation of NAD⁺ pathways could lead to methylation depletion or interfere with sirtuin balance.

  • Caution is advised with:

    • Chemotherapy drugs (may interfere with NAD⁺-dependent cancer pathways)

    • PARP inhibitors

    • Immunosuppressants                                                                                                                                         Always consult a healthcare provider if you are on any long-term medication.

DISCLAIMER :

DISCLAIMER :

As stated in the short description, this and other products of subsection of
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The information provided in the descriptions of products which can be found into “Nootropics” subsection – as available from ethosherbals.com, SMARTSHOP Main Category– is of an academic nature. This information is not intended to be used for human consumption of the products in question. It is not intended to diagnose, prevent or treat any medical condition. It is not intended to be a substitute for any medical treatment.


											
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